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Zentalis Pharmaceuticals, Inc. (ZNTL)

Healthcare | Biotechnology | San Diego, United States | NasdaqGM
4.64 USD -0.38 (-7.570%) ⇩ (April 17, 2026, 4 p.m. EDT)
After hours: 4.75 +0.11 (2.349%) ⇧ (April 17, 2026, 7:49 p.m. EDT)

Short-term: ★★☆☆☆ | Long-term: ★☆☆☆☆ | Dividends: ☆☆☆☆☆
Hot Take | April 19, 2026, 12:13 a.m. EDT

ZNTL faces a severe gamma squeeze risk with massive put OI at $2.00 and $1.00 creating a thick 'dam' for the stock to break through in the short term. While the catalyst-driven rally is interesting, the premium sell-side pressure in the options chain makes any breakout attempt fragile. Without a massive volume spike to overcome the put OI at $2.50 and below, the stock offers poor risk-reward for a near-term momentum play; the high autocorrelation/mean-reversion stats on the forecast model further suggest a low probability of a sustained trend in the next 45 days, aligning with the heavy hedge positioning.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoARIMA ✓0.073319
AutoETS0.132394
MSTL0.146662
AutoTheta0.419641

Forecast horizon: 45 days | Selected: AutoARIMA

Forecast Reliability
Score 33%
H-stat 3.30
Ljung-Box p 0.450
Jarque-Bera p 0.000
Excess Kurtosis 9.41
Attribute Value
Sector Healthcare
Debt to Equity Ratio 18.305
Market Cap 329,119,904
Forward P/E -2.98
Beta 1.66
Website https://zentalis.com

As of April 19, 2026, 12:13 a.m. EDT: Options activity shows heavy put positioning relative to open interest (OI) due strikes below the current price of $4.64, particularly at the $2.00 and $1.00 levels, indicating strong downside protection hedging by major holders. This bears a 'put compress' effect. While there is some ATM OI at near-term expirations, the sheer volume at OTM puts dilutes the bullish intraday signals from the $5.00 strike. The high implied volatility (IV) at deep OTM strikes suggests market pricing in a high probability of a move lower or significant volatility event avoidance strategies.


Info Dump

Attribute Value
52 Week Change 2.4117646
Address1 10,275 Science Center Dr.
Address2 Suite 200
All Time High 87.19
All Time Low 1.01
Ask 4.67
Ask Size 2
Average Analyst Rating 2.1 - Buy
Average Daily Volume10 Day 7,947,600
Average Daily Volume3 Month 1,824,172
Average Volume 1,824,172
Average Volume10Days 7,947,600
Beta 1.659
Bid 4.58
Bid Size 2
Book Value 3.129
City San Diego
Compensation As Of Epoch Date 1,735,603,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 4.64
Current Ratio 6.926
Custom Price Alert Confidence HIGH
Date Short Interest 1,774,915,200
Day High 5.23
Day Low 4.38
Debt To Equity 18.305
Display Name Zentalis Pharmaceuticals
Earnings Timestamp 1,774,555,200
Earnings Timestamp End 1,778,788,800
Earnings Timestamp Start 1,778,788,800
Ebitda -140,136,992
Ebitda Margins 0.0
Enterprise To Ebitda -0.876
Enterprise Value 122,803,912
Eps Current Year -1.77
Eps Forward -1.555
Eps Trailing Twelve Months -1.91
Esg Populated 0
Exchange NGM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 2.8881
Fifty Day Average Change 1.7519
Fifty Day Average Change Percent 0.6065926
Fifty Two Week Change Percent 241.17647
Fifty Two Week High 6.95
Fifty Two Week High Change -2.31
Fifty Two Week High Change Percent -0.3323741
Fifty Two Week Low 1.13
Fifty Two Week Low Change 3.5099998
Fifty Two Week Low Change Percent 3.1061945
Fifty Two Week Range 1.13 - 6.95
Financial Currency USD
First Trade Date Milliseconds 1,585,920,600,000
Float Shares 48,666,479
Forward Eps -1.555
Forward P E -2.983923
Free Cashflow -75,869,504
Full Exchange Name NasdaqGM
Full Time Employees 106
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.0
Has Pre Post Market Data 1
Held Percent Insiders 0.22353001
Held Percent Institutions 0.63202
Implied Shares Outstanding 70,931,016
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Zentalis Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics for the treatment of various cancers in the United States. The company develops azenosertib, which is in a Phase 3 clinical trial for the treatment of ovarian cancer and other tumor types. It also develops ZN-c3-001, a phase 1 study that evaluated azenosertib monotherapy in solid tumors; and MAMMOTH (ZN-c3-006) is a Phase 1/2 clinical trial of azenosertib in patients with PARP-inhibitor resistant ovarian cancer. It has licensing agreements and strategic collaborations with Recurium IP Holdings, LLC. Zentalis Pharmaceuticals, Inc. was incorporated in 2014 and is headquartered in San Diego, California.
Long Name Zentalis Pharmaceuticals, Inc.
Market us_market
Market Cap 329,119,904
Market State CLOSED
Max Age 86,400
Message Board Id finmb_647536411
Most Recent Quarter 1,767,139,200
Net Income To Common -137,060,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 328,410,604
Number Of Analyst Opinions 8
Open 5.17
Operating Cashflow -125,247,000
Operating Margins 0.0
Payout Ratio 0.0
Phone 212 433 3791
Post Market Change 0.109000206
Post Market Change Percent 2.3491426
Post Market Price 4.749
Post Market Time 1,776,469,785
Previous Close 5.02
Price Eps Current Year -2.6214688
Price Hint 4
Price To Book 1.4829018
Profit Margins 0.0
Quick Ratio 6.726
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key buy
Recommendation Mean 2.11111
Region US
Regular Market Change -0.38
Regular Market Change Percent -7.56972
Regular Market Day High 5.23
Regular Market Day Low 4.38
Regular Market Day Range 4.38 - 5.23
Regular Market Open 5.17
Regular Market Previous Close 5.02
Regular Market Price 4.64
Regular Market Time 1,776,456,000
Regular Market Volume 2,284,230
Return On Assets -0.24481001
Return On Equity -0.49535
Sand P52 Week Change 0.38150132
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 70,931,016
Shares Percent Shares Out 0.060100004
Shares Short 4,260,634
Shares Short Previous Month Date 1,772,150,400
Shares Short Prior Month 3,775,935
Short Name Zentalis Pharmaceuticals, Inc.
Short Percent Of Float 0.0753
Short Ratio 6.76
Source Interval 15
State CA
Symbol ZNTL
Target High Price 10.0
Target Low Price 2.0
Target Mean Price 6.25
Target Median Price 5.5
Total Cash 245,892,992
Total Cash Per Share 3.467
Total Debt 39,577,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -1.91
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 1.9777
Two Hundred Day Average Change 2.6622999
Two Hundred Day Average Change Percent 1.3461596
Type Disp Equity
Volume 2,284,230
Website https://zentalis.com
Zip 92,121