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Xilio Therapeutics, Inc. (XLO)

Healthcare | Biotechnology | Waltham, United States | NasdaqCM
9.00 USD +0.08 (0.897%) ⇧ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 9.02 +0.02 (0.222%) ⇧ (Aug. 28, 2026, 4:35 p.m. EDT)

Short-term:★★⯪☆☆Long-term:★☆☆☆☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 2:21 a.m. EDT

The immediate outlook remains flat due to a severe disconnect between the company's deteriorating financial reality and the optimistic analyst consensus. While a single analyst rates this as a 'strong buy' with a $20 target, the underlying data tells a different story: the stock has lost over 70% of its value over the last three years, driven by two consecutive years of significant declines (-21% and -68%). This multi-year trajectory suggests the market has already priced out the risks associated with the business model, rendering the bullish analyst call premature. Fundamentally, the company is burning through cash with negative operating margins and no revenue growth to speak of, despite a 131% reported revenue growth figure that likely reflects a base effect or one-time event rather than sustainable expansion. The balance sheet, while currently showing low debt, is propped up by cash reserves that are being consumed rapidly by operations. With no dividend to provide income and a price history indicating structural weakness, there is no compelling case for a near-term bounce or a long-term hold at these levels.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.025679
AutoETS0.030618
AutoTheta0.041670
AutoARIMA0.057640

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 32%
H-stat 0.89
Ljung-Box p 0.000
Jarque-Bera p 0.001
Excess Kurtosis 1.67
Attribute Value
Sector Healthcare
Debt to Equity Ratio 8.722
Revenue per Share 9.74
Market Cap 59,221,376
Forward P/E -15.52
Beta -0.12
Profit Margins -34.06%
Website https://xiliotx.com

Info Dump

Attribute Value
52 Week Change -0.08713275
Address1 828 Winter Street
Address2 Suite 300
All Time High 391.3
All Time Low 6.468
Ask 11.9
Ask Size 2
Average Analyst Rating 1.0 - Strong Buy
Average Daily Volume10 Day 11,100
Average Daily Volume3 Month 32,401
Average Volume 32,488
Average Volume10Days 11,100
Beta -0.119
Bid 6.48
Bid Size 2
Book Value 7.785
City Waltham
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 9.0
Current Ratio 4.254
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 9.0001
Day Low 8.995
Debt To Equity 8.722
Display Name Xilio Therapeutics
Earnings Timestamp End 1,754,911,858
Earnings Timestamp Start 1,754,479,858
Ebitda -30,030,000
Ebitda Margins -0.46855
Enterprise To Ebitda 2.348
Enterprise To Revenue -1.1
Enterprise Value -70,515,624
Eps Forward -0.58
Eps Trailing Twelve Months -0.32
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 9.0782
Fifty Day Average Change -0.07820034
Fifty Day Average Change Percent -0.00861408
Fifty Two Week Change Percent -8.061224
Fifty Two Week High 12.74
Fifty Two Week High Change -3.7399998
Fifty Two Week High Change Percent -0.29356357
Fifty Two Week Low 6.468
Fifty Two Week Low Change 2.532
Fifty Two Week Low Change Percent 0.3914657
Fifty Two Week Range 6.468 - 12.74
Financial Currency USD
First Trade Date Milliseconds 1,634,909,400,000
Float Shares 3,402,531
Forward Eps -0.58
Forward P E -15.5172415
Free Cashflow -37,562,000
Full Exchange Name NasdaqCM
Full Time Employees 76
Fullday Change 0.0799999
Fullday Change Percent 0.89686
Fullday Price 9.02
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.83156997
Gross Profits 53,297,000
Has Pre Post Market Data 1
Held Percent Insiders 0.25982
Held Percent Institutions 0.50136
Implied Shares Outstanding 6,580,153
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,021-10-22
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,773,619,200
Last Split Factor 1:14
Long Business Summary Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of masked immuno-oncology therapies. The company's pipeline includes XTX501, a bispecific PD-1 / masked IL-2, for patients with metastatic non-small cell lung cancer; Efarindodekin alfa, an investigational, masked IL-12, that is in Phase 2 clinical trial for patients with advanced solid tumors; and Vilastobart, an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody. The company was founded in 2016 and is headquartered in Waltham, Massachusetts.
Long Name Xilio Therapeutics, Inc.
Market us_market
Market Cap 59,221,376
Market State CLOSED
Max Age 86,400
Message Board Id finmb_365333564
Most Recent Quarter 1,782,777,600
Net Income To Common -21,829,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 58,694,964
Number Of Analyst Opinions 1
Open 8.995
Operating Cashflow -60,598,000
Operating Margins -0.18676001
Payout Ratio 0.0
Phone 857 524 2466
Post Market Change 0.020000458
Post Market Change Percent 0.2222273
Post Market Price 9.02
Post Market Time 1,787,949,322
Previous Close 8.92
Price Hint 2
Price To Book 1.1560694
Price To Sales Trailing12 Months 0.92400575
Profit Margins -0.34058997
Quick Ratio 4.153
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.0
Region US
Regular Market Change 0.07999992
Regular Market Change Percent 0.8968601
Regular Market Day High 9.28
Regular Market Day Low 8.995
Regular Market Day Range 8.995 - 9.28
Regular Market Open 8.995
Regular Market Previous Close 8.92
Regular Market Price 9.0
Regular Market Time 1,787,947,200
Regular Market Volume 3,530
Return On Assets -0.13611001
Return On Equity -0.55030996
Revenue Growth 1.312
Revenue Per Share 9.74
Sand P52 Week Change 0.1966995
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 6,580,153
Shares Percent Shares Out 0.0641
Shares Short 421,921
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 268,180
Short Name Xilio Therapeutics, Inc.
Short Percent Of Float 0.0716
Short Ratio 13.74
Source Interval 15
State MA
Symbol XLO
Target High Price 20.0
Target Low Price 20.0
Target Mean Price 20.0
Target Median Price 20.0
Total Cash 136,040,000
Total Cash Per Share 20.674
Total Debt 6,303,000
Total Revenue 64,092,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -0.32
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 8.745045
Two Hundred Day Average Change 0.2549553
Two Hundred Day Average Change Percent 0.029154258
Type Disp Equity
Volume 3,530
Website https://xiliotx.com
Zip 2,451