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Xilio Therapeutics, Inc. (XLO)

Healthcare | Biotechnology | Waltham, United States | NasdaqCM
9.24 USD +0.09 (0.984%) ⇧ (July 13, 2026, 4 p.m. EDT)

Short-term:★★⯪☆☆Long-term:⯪☆☆☆☆Dividends:☆☆☆☆☆
Hot Take | July 11, 2026, 4:11 a.m. EDT

The stock is currently trading near its 52-week lows, having suffered a catastrophic multi-year decline where the price has lost over 75% of its value in just three years. This trajectory is driven by three consecutive years of negative annual returns, signaling severe structural deterioration rather than a temporary setback. While the company recently beat revenue estimates and received a 'Buy' upgrade, these positive headlines cannot override the reality of a business burning through cash, reporting massive losses, and failing to generate free cash flow. The balance sheet, though currently liquid, faces existential risks typical of a biotech firm with no commercialized products and significant operating deficits. With no dividend history and a negative earnings outlook, there is no safety net for investors. The recent price action shows some minor stabilization, but the fundamental damage is too deep to support a bullish short-term thesis.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoARIMA ✓0.047737
MSTL0.056790
AutoETS0.057206
AutoTheta0.065827

Forecast horizon: 45 days | Selected: AutoARIMA

Forecast Reliability
Score 40%
H-stat 5.25
Ljung-Box p 0.000
Jarque-Bera p 0.336
Excess Kurtosis -0.63
Attribute Value
Sector Healthcare
Debt to Equity Ratio 9.15
Revenue per Share 9.249
Market Cap 60,754,284
Forward P/E -15.93
Beta -0.12
Profit Margins -58.52%
Website https://xiliotx.com

Info Dump

Attribute Value
52 Week Change -0.12162161
Address1 828 Winter Street
Address2 Suite 300
All Time High 391.3
All Time Low 6.468
Ask 11.64
Ask Size 2
Average Daily Volume10 Day 57,220
Average Daily Volume3 Month 46,811
Average Volume 46,811
Average Volume10Days 57,220
Beta -0.122
Bid 6.72
Bid Size 2
Book Value 7.785
City Waltham
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 9.24
Current Ratio 3.59
Custom Price Alert Confidence HIGH
Date Short Interest 1,782,777,600
Day High 9.32
Day Low 8.98
Debt To Equity 9.15
Display Name Xilio Therapeutics
Earnings Timestamp End 1,754,911,858
Earnings Timestamp Start 1,754,479,858
Ebitda -40,855,000
Ebitda Margins -0.76387
Enterprise To Ebitda 2.164
Enterprise To Revenue -1.653
Enterprise Value -88,413,568
Eps Forward -0.58
Eps Trailing Twelve Months -2.28
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 8.4406
Fifty Day Average Change 0.7993994
Fifty Day Average Change Percent 0.09470883
Fifty Two Week Change Percent -12.162161
Fifty Two Week High 12.74
Fifty Two Week High Change -3.5
Fifty Two Week High Change Percent -0.2747253
Fifty Two Week Low 6.468
Fifty Two Week Low Change 2.7719998
Fifty Two Week Low Change Percent 0.4285714
Fifty Two Week Range 6.468 - 12.74
Financial Currency USD
First Trade Date Milliseconds 1,634,909,400,000
Float Shares 3,752,078
Forward Eps -0.58
Forward P E -15.931034
Free Cashflow -23,032,876
Full Exchange Name NasdaqCM
Full Time Employees 76
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.79128
Gross Profits 42,321,000
Has Pre Post Market Data 1
Held Percent Insiders 0.28576002
Held Percent Institutions 0.51838
Implied Shares Outstanding 6,575,139
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,021-10-22
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,773,619,200
Last Split Factor 1:14
Long Business Summary Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of masked immuno-oncology therapies. The company's pipeline includes XTX501, a bispecific PD-1 / masked IL-2, for patients with metastatic non-small cell lung cancer; Efarindodekin alfa, an investigational, masked IL-12, that is in Phase 2 clinical trial for patients with advanced solid tumors; and Vilastobart, an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody. The company was founded in 2016 and is headquartered in Waltham, Massachusetts.
Long Name Xilio Therapeutics, Inc.
Market us_market
Market Cap 60,754,284
Market State PRE
Max Age 86,400
Message Board Id finmb_365333564
Most Recent Quarter 1,774,915,200
Net Income To Common -31,300,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 59,833,764
Number Of Analyst Opinions 1
Open 9.1
Operating Cashflow -56,313,000
Operating Margins -1.11575
Payout Ratio 0.0
Phone 857 524 2466
Previous Close 9.15
Price Hint 2
Price To Book 1.1868979
Price To Sales Trailing12 Months 1.1359338
Profit Margins -0.58522
Quick Ratio 3.499
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change 0.0900002
Regular Market Change Percent 0.983608
Regular Market Day High 9.32
Regular Market Day Low 8.98
Regular Market Day Range 8.98 - 9.32
Regular Market Open 9.1
Regular Market Previous Close 9.15
Regular Market Price 9.24
Regular Market Time 1,783,972,800
Regular Market Volume 71,378
Return On Assets -0.19761999
Return On Equity -0.752
Revenue Growth 3.317
Revenue Per Share 9.249
Sand P52 Week Change 0.20847368
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 6,575,139
Shares Percent Shares Out 0.026600001
Shares Short 174,619
Shares Short Previous Month Date 1,780,012,800
Shares Short Prior Month 165,274
Short Name Xilio Therapeutics, Inc.
Short Percent Of Float 0.0297
Short Ratio 4.84
Source Interval 15
State MA
Symbol XLO
Target High Price 20.0
Target Low Price 20.0
Target Mean Price 20.0
Target Median Price 20.0
Total Cash 150,332,992
Total Cash Per Share 25.127
Total Debt 6,638,000
Total Revenue 53,484,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -2.28
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 9.108125
Two Hundred Day Average Change 0.13187504
Two Hundred Day Average Change Percent 0.014478835
Type Disp Equity
Volume 71,378
Website https://xiliotx.com
Zip 2,451