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Xeris Biopharma Holdings, Inc. (XERS)

Healthcare | Drug Manufacturers - Specialty & Generic | Chicago, United States | NasdaqGS
8.16 USD -0.18 (-2.158%) ⇩ (July 13, 2026, 4 p.m. EDT)
After hours: 8.10 -0.06 (-0.060%) ⇩ (July 13, 2026, 7:11 p.m. EDT)

Short-term:★★★★☆Long-term:★★★☆☆Dividends:☆☆☆☆☆
Hot Take | July 11, 2026, 2:56 a.m. EDT

The immediate outlook is driven by a powerful confluence of technical momentum and speculative positioning. The stock has surged nearly 23% over the last fifty days, breaking above its moving averages, which aligns perfectly with the aggressive call buying seen in the options chain. Speculators are clearly betting on a continuation of this trend, targeting the $10 level where significant open interest sits. This creates a high-conviction short-term bullish case, supported by the recent catalyst of a patent win and extended exclusivity on Keveyis. However, the long-term picture remains precarious due to the company's precarious financial structure. While the business shows signs of recovery with a massive 118% revenue jump last year and a forward P/E that looks reasonable relative to current earnings, the balance sheet is a ticking time bomb. The company carries nearly $260 million in debt against only $112 million in cash, resulting in a debt-to-equity ratio of nearly 2,000%. This leverage makes the stock extremely sensitive to any regulatory setbacks or delays in drug development. The market is currently pricing in a successful path to profitability, but the lack of a dividend and the thin margin of safety regarding liquidity mean this is a high-risk, high-reward play rather than a stable investment.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoTheta ✓0.072337
AutoARIMA0.086755
AutoETS0.087028
MSTL0.088014

Forecast horizon: 45 days | Selected: AutoTheta

Forecast Reliability
Score 30%
H-stat 25.73
Ljung-Box p 0.000
Jarque-Bera p 0.020
Excess Kurtosis 0.24
Attribute Value
Sector Healthcare
Debt to Equity Ratio 1987.188
Revenue per Share 1.909
Market Cap 1,408,759,040
Trailing P/E 116.57
Forward P/E 20.79
Beta 0.85
Profit Margins 3.81%
Previous Name Xeris Pharmaceuticals, Inc.
Website https://www.xerispharma.com

As of July 11, 2026, 2:56 a.m. EDT: Speculators are heavily positioned for upside, evidenced by massive open interest in out-of-the-money calls at the $10 strike compared to negligible put volume. The call chain shows significant interest in $10 targets across multiple expirations, while put activity is almost entirely concentrated in deep out-of-the-money strikes ($5), suggesting a bullish bias rather than hedging against a crash.


Info Dump

Attribute Value
52 Week Change 0.5330882
Address1 1,375 West Fulton Street
Address2 Suite 1300
All Time High 27.98
All Time Low 0.97
Ask 10.4
Ask Size 2
Audit Risk 5
Average Analyst Rating 1.4 - Strong Buy
Average Daily Volume10 Day 3,026,060
Average Daily Volume3 Month 1,871,786
Average Volume 1,871,786
Average Volume10Days 3,026,060
Beta 0.85
Bid 5.94
Bid Size 2
Board Risk 7
Book Value 0.082
City Chicago
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 8
Country United States
Crypto Tradeable 0
Currency USD
Current Price 8.16
Current Ratio 2.122
Custom Price Alert Confidence HIGH
Date Short Interest 1,782,777,600
Day High 8.345
Day Low 8.05
Debt To Equity 1,987.188
Display Name Xeris Biopharma
Earnings Call Timestamp End 1,778,157,000
Earnings Call Timestamp Start 1,778,157,000
Earnings Timestamp 1,778,157,000
Earnings Timestamp End 1,786,019,400
Earnings Timestamp Start 1,786,019,400
Ebitda 48,080,000
Ebitda Margins 0.15271
Enterprise To Ebitda 32.354
Enterprise To Revenue 4.941
Enterprise Value 1,555,562,112
Eps Current Year 0.14
Eps Forward 0.3925
Eps Trailing Twelve Months 0.07
Esg Populated 0
Exchange NMS
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 6.8048
Fifty Day Average Change 1.3551998
Fifty Day Average Change Percent 0.19915351
Fifty Two Week Change Percent 53.308823
Fifty Two Week High 10.08
Fifty Two Week High Change -1.9200001
Fifty Two Week High Change Percent -0.1904762
Fifty Two Week Low 4.87
Fifty Two Week Low Change 3.29
Fifty Two Week Low Change Percent 0.6755647
Fifty Two Week Range 4.87 - 10.08
Financial Currency USD
First Trade Date Milliseconds 1,529,587,800,000
Float Shares 166,280,195
Forward Eps 0.3925
Forward P E 20.789808
Free Cashflow 42,205,376
Full Exchange Name NasdaqGS
Full Time Employees 435
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,782,864,000
Gross Margins 0.85893
Gross Profits 270,438,016
Has Pre Post Market Data 1
Held Percent Insiders 0.033800002
Held Percent Institutions 0.62473
Implied Shares Outstanding 172,642,055
Industry Drug Manufacturers - Specialty & Generic
Industry Disp Drug Manufacturers - Specialty & Generic
Industry Key drug-manufacturers-specialty-generic
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Xeris Biopharma Holdings, Inc., a commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois. It offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia in pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It is also developing XP-8121, a once-weekly subcutaneous injection of levothyroxine that is in phase 3 clinical trial for the treatment of hypothyroidism. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.
Long Name Xeris Biopharma Holdings, Inc.
Market us_market
Market Cap 1,408,759,040
Market State PREPRE
Max Age 86,400
Message Board Id finmb_105901792
Most Recent Quarter 1,774,915,200
Name Change Date 2,026-07-13
Net Income To Common 12,008,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 1,441,561,159
Number Of Analyst Opinions 7
Open 8.34
Operating Cashflow 48,527,000
Operating Margins 0.09523
Overall Risk 7
Payout Ratio 0.0
Phone 844 445 5704
Post Market Change -0.059999466
Post Market Change Percent -0.7352876
Post Market Price 8.1
Post Market Time 1,783,984,305
Prev Name Xeris Pharmaceuticals, Inc.
Previous Close 8.34
Price Eps Current Year 58.285713
Price Hint 2
Price To Book 99.51219
Price To Sales Trailing12 Months 4.474339
Profit Margins 0.03814
Quick Ratio 1.417
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.42857
Region US
Regular Market Change -0.18
Regular Market Change Percent -2.15828
Regular Market Day High 8.345
Regular Market Day Low 8.05
Regular Market Day Range 8.05 - 8.345
Regular Market Open 8.34
Regular Market Previous Close 8.34
Regular Market Price 8.16
Regular Market Time 1,783,972,800
Regular Market Volume 1,461,452
Return On Assets 0.06343
Revenue Growth 0.383
Revenue Per Share 1.909
Sand P52 Week Change 0.20847368
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 8
Shares Outstanding 172,642,055
Shares Percent Shares Out 0.0739
Shares Short 12,760,034
Shares Short Previous Month Date 1,780,012,800
Shares Short Prior Month 12,514,253
Short Name Xeris Biopharma Holdings, Inc.
Short Percent Of Float 0.0765
Short Ratio 6.2
Source Interval 15
State IL
Symbol XERS
Target High Price 18.0
Target Low Price 8.0
Target Mean Price 11.28571
Target Median Price 10.0
Total Cash 111,750,000
Total Cash Per Share 0.647
Total Debt 258,552,992
Total Revenue 314,852,992
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps 0.07
Trailing P E 116.57143
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 7.05725
Two Hundred Day Average Change 1.1027498
Two Hundred Day Average Change Percent 0.15625772
Type Disp Equity
Volume 1,461,452
Website https://www.xerispharma.com
Zip 60,607