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Xeris Biopharma Holdings, Inc. (XERS)

Healthcare | Drug Manufacturers - Specialty & Generic | Chicago, United States | NasdaqGS
8.48 USD -0.12 (-1.395%) ⇩ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 8.48

Short-term:★★★⯪☆Long-term:★★★★☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 5:20 a.m. EDT

The investment case here is a classic turnaround story where the market has priced in a disaster, yet the operational reality suggests a recovery is underway. Fundamentally, the company is showing signs of life with revenue growing nearly 29% year-over-year and gross margins expanding to 86.6%. Crucially, the multi-year price trajectory tells a different story than the headline numbers; despite four years of losses, the stock has surged 176% in the trailing twelve months, erasing a massive portion of its historical decline. This suggests the market is finally recognizing the value of their extended exclusivity on Keveyis and the recent patent wins. However, the path forward remains precarious. The balance sheet is fragile, with debt nearly double the cash on hand, and the company is still burning cash, evidenced by negative profit margins. While the recent price action shows strong momentum—trading well above its 50-day and 200-day averages—the statistical forecasting models are currently weak and leaning slightly negative, likely reflecting the high volatility and uncertainty surrounding biotech trials. The options market is screaming 'upside,' with no hedging activity visible, which aligns with the bullish sentiment but adds significant tail risk if the next catalyst misses expectations. For a patient investor willing to tolerate the binary nature of biotech, the valuation appears attractive relative to the growth rate, but the lack of a dividend and the thin balance sheet mean this is strictly a growth play, not a value hold.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.256471
AutoTheta0.267916
AutoETS0.268823
AutoARIMA0.274825

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 42%
H-stat 5.30
Ljung-Box p 0.000
Jarque-Bera p 0.093
Excess Kurtosis -0.62
Attribute Value
Sector Healthcare
Revenue per Share 1.993
Market Cap 1,546,076,032
Forward P/E 21.74
Beta 0.85
Profit Margins -5.12%
Previous Name Xeris Pharmaceuticals, Inc.
Website https://www.xerispharma.com

As of Aug. 22, 2026, 5:20 a.m. EDT: Speculators are overwhelmingly bullish, with open interest concentrated entirely in out-of-the-money calls across all expirations. There is zero put volume recorded, indicating a complete absence of hedging or bearish positioning. Call open interest peaks significantly at the $10 strike, suggesting a collective expectation of a move toward or above that level within the next few months.


Info Dump

Attribute Value
52 Week Change 0.08585858
Address1 1,375 West Fulton Street
Address2 Suite 1300
All Time High 27.98
All Time Low 0.97
Ask 10.75
Ask Size 2
Audit Risk 5
Average Analyst Rating 1.4 - Strong Buy
Average Daily Volume10 Day 1,531,120
Average Daily Volume3 Month 1,888,279
Average Volume 1,888,279
Average Volume10Days 1,531,120
Beta 0.852
Bid 7.61
Bid Size 3
Board Risk 8
Book Value -0.056
City Chicago
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 8
Country United States
Crypto Tradeable 0
Currency USD
Current Price 8.48
Current Ratio 1.449
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 8.675
Day Low 8.375
Display Name Xeris Biopharma
Earnings Call Timestamp End 1,786,019,400
Earnings Call Timestamp Start 1,786,019,400
Earnings Timestamp 1,786,019,400
Earnings Timestamp End 1,793,881,800
Earnings Timestamp Start 1,793,881,800
Ebitda 48,769,000
Ebitda Margins 0.1454
Enterprise To Ebitda 35.141
Enterprise To Revenue 5.109
Enterprise Value 1,713,771,136
Eps Current Year -0.00333
Eps Forward 0.39
Eps Trailing Twelve Months -0.1
Esg Populated 0
Exchange NMS
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 8.23
Fifty Day Average Change 0.25
Fifty Day Average Change Percent 0.030376673
Fifty Two Week Change Percent 8.585858
Fifty Two Week High 10.08
Fifty Two Week High Change -1.6000004
Fifty Two Week High Change Percent -0.1587302
Fifty Two Week Low 5.25
Fifty Two Week Low Change 3.2299995
Fifty Two Week Low Change Percent 0.615238
Fifty Two Week Range 5.25 - 10.08
Financial Currency USD
First Trade Date Milliseconds 1,529,587,800,000
Float Shares 175,948,211
Forward Eps 0.39
Forward P E 21.74359
Free Cashflow 52,450,124
Full Exchange Name NasdaqGS
Full Time Employees 435
Fullday Change -0.120001
Fullday Change Percent -1.39536
Fullday Price 8.48
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,785,542,400
Gross Margins 0.86574996
Gross Profits 290,384,992
Has Pre Post Market Data 1
Held Percent Insiders 0.03083
Held Percent Institutions 0.59956
Implied Shares Outstanding 182,320,306
Industry Drug Manufacturers - Specialty & Generic
Industry Disp Drug Manufacturers - Specialty & Generic
Industry Key drug-manufacturers-specialty-generic
Is Earnings Date Estimate 0
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Xeris Biopharma Holdings, Inc., a commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois. It offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia in pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It is also developing XP-8121, a once-weekly subcutaneous injection of levothyroxine that is in phase 3 clinical trial for the treatment of hypothyroidism. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.
Long Name Xeris Biopharma Holdings, Inc.
Market us_market
Market Cap 1,546,076,032
Market State CLOSED
Max Age 86,400
Message Board Id finmb_105901792
Most Recent Quarter 1,782,777,600
Name Change Date 2,026-08-28
Net Income To Common -17,165,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 1,567,954,631
Number Of Analyst Opinions 7
Open 8.61
Operating Cashflow 56,608,000
Operating Margins 0.05617
Overall Risk 8
Payout Ratio 0.0
Phone 844 445 5704
Post Market Change 0.0
Post Market Change Percent 0.0
Post Market Price 8.48
Post Market Time 1,787,959,804
Prev Name Xeris Pharmaceuticals, Inc.
Previous Close 8.6
Price Eps Current Year -2,546.5464
Price Hint 2
Price To Book -151.42856
Price To Sales Trailing12 Months 4.6094556
Profit Margins -0.05118
Quick Ratio 0.949
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.42857
Region US
Regular Market Change -0.120001
Regular Market Change Percent -1.39536
Regular Market Day High 8.675
Regular Market Day Low 8.375
Regular Market Day Range 8.375 - 8.675
Regular Market Open 8.61
Regular Market Previous Close 8.6
Regular Market Price 8.48
Regular Market Time 1,787,947,201
Regular Market Volume 1,027,270
Return On Assets 0.06127
Revenue Growth 0.287
Revenue Per Share 1.993
Sand P52 Week Change 0.20504117
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 8
Shares Outstanding 182,320,306
Shares Percent Shares Out 0.0479
Shares Short 8,728,856
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 10,078,469
Short Name Xeris Biopharma Holdings, Inc.
Short Percent Of Float 0.0494
Short Ratio 5.33
Source Interval 15
State IL
Symbol XERS
Target High Price 18.0
Target Low Price 8.0
Target Mean Price 11.71429
Target Median Price 12.0
Total Cash 121,747,000
Total Cash Per Share 0.668
Total Debt 289,441,984
Total Revenue 335,414,016
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -0.1
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 7.01115
Two Hundred Day Average Change 1.4688497
Two Hundred Day Average Change Percent 0.20950197
Type Disp Equity
Volume 1,027,270
Website https://www.xerispharma.com
Zip 60,607