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VYNE Therapeutics Inc. (VYNE)

Healthcare | Biotechnology | Stewartsville, United States | NasdaqCM
0.66 USD +0.02 (3.184%) ⇧ (July 13, 2026, 4 p.m. EDT)

Short-term:★☆☆☆☆Long-term:☆☆☆☆☆Dividends:★★⯪☆☆
Hot Take | July 11, 2026, 5:18 a.m. EDT

The investment case here is fundamentally broken. The business has suffered a catastrophic multi-year decline, dropping nearly 99.8% over the last seven years with every single year showing negative growth. This is not a temporary setback; the company is burning through cash, reporting massive losses, and shrinking revenues while trading at a negative forward P/E. The recent price action shows no recovery, hovering near multi-year lows with a low-volume bounce that lacks conviction. While there is a headline-grabbing special dividend tied to a potential merger, this is a one-time event that does not fix the deteriorating core business. The statistical models also predict further downside in the near term, confirming the lack of momentum. This is a clear avoid.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL_126 ✓0.045969
MSTL0.050109
AutoETS0.053123
MSTL_74_1260.098339
MSTL_740.135497
AutoTheta0.145130
AutoARIMA0.177340

Forecast horizon: 60 days | Selected: MSTL_126

Forecast Reliability
Score 32%
H-stat 5.18
Ljung-Box p 0.000
Jarque-Bera p 0.680
Excess Kurtosis -0.20
Attribute Value
Sector Healthcare
Ex Dividend Date 2026-07-21
Revenue per Share 0.011
Market Cap 21,964,028
Forward P/E -0.40
Beta 2.01
Previous Name Menlo Therapeutics Inc.
Website https://vynetherapeutics.com

Info Dump

Attribute Value
52 Week Change -0.52030075
Address1 P.O. BOX 125
All Time High 2,869.92
All Time Low 0.281
Ask 0.832
Ask Size 2
Average Daily Volume10 Day 1,778,560
Average Daily Volume3 Month 430,650
Average Volume 430,650
Average Volume10Days 1,778,560
Beta 2.006
Bid 0.4758
Bid Size 2
Book Value 0.739
City Stewartsville
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 0.6579
Current Ratio 20.865
Custom Price Alert Confidence HIGH
Date Short Interest 1,782,777,600
Day High 0.6919
Day Low 0.635
Display Name VYNE Therapeutics
Earnings Timestamp End 1,755,520,200
Earnings Timestamp Start 1,755,001,800
Ebitda -24,345,000
Ebitda Margins 0.0
Enterprise To Ebitda 0.123
Enterprise To Revenue -6.575
Enterprise Value -2,985,154
Eps Current Year -1.1
Eps Forward -1.65
Eps Trailing Twelve Months -0.53
Esg Populated 0
Ex Dividend Date 1,784,678,400
Exchange NCM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 0.66114
Fifty Day Average Change -0.003240049
Fifty Day Average Change Percent -0.0049007
Fifty Two Week Change Percent -52.030075
Fifty Two Week High 1.595
Fifty Two Week High Change -0.93710005
Fifty Two Week High Change Percent -0.5875235
Fifty Two Week Low 0.281
Fifty Two Week Low Change 0.3769
Fifty Two Week Low Change Percent 1.3412812
Fifty Two Week Range 0.281 - 1.595
Financial Currency USD
First Trade Date Milliseconds 1,516,890,600,000
Float Shares 30,544,547
Forward Eps -1.65
Forward P E -0.39872727
Free Cashflow -20,400,000
Full Exchange Name NasdaqCM
Full Time Employees 10
Gmt Off Set Milliseconds -14,400,000
Gross Margins 1.0
Gross Profits 454,000
Has Pre Post Market Data 1
Held Percent Insiders 0.101160005
Held Percent Institutions 0.39581
Implied Shares Outstanding 33,385,055
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,676,246,400
Last Split Factor 1:18
Long Business Summary VYNE Therapeutics Inc., a clinical-stage biopharmaceutical company, focuses on developing therapies to treat chronic inflammatory and immune-mediated conditions. The company's lead program is repibresib gel (VYN201), a topically administered small molecule pan-bromodomain and extra-terminal (BET) inhibitor soft drug to address diseases involving multiple and diverse inflammatory cell signaling pathways with low systemic exposure. It also develops VYN202, a BD2-selective oral small molecule BET inhibitor in Phase 1b trial for the acute control and chronic management of immune-mediated inflammatory conditions. VYNE Therapeutics Inc. was formerly known as Menlo Therapeutics Inc. and changed its name to VYNE Therapeutics Inc. in September 2020. The company was founded in 2003 and is based in Stewartsville, New Jersey.
Long Name VYNE Therapeutics Inc.
Market us_market
Market Cap 21,964,028
Market State PRE
Max Age 86,400
Message Board Id finmb_6511914
Most Recent Quarter 1,774,915,200
Name Change Date 2,026-07-13
Net Income To Common -21,718,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 21,286,311
Open 0.635
Operating Cashflow -25,744,000
Operating Margins -44.37209
Payout Ratio 0.0
Phone 800 775 7936
Pre Market Change 0.026600003
Pre Market Change Percent 4.043168
Pre Market Price 0.6845
Pre Market Time 1,784,016,020
Prev Name Menlo Therapeutics Inc.
Previous Close 0.6376
Price Eps Current Year -0.5980909
Price Hint 4
Price To Book 0.89025706
Price To Sales Trailing12 Months 48.378918
Profit Margins 0.0
Quick Ratio 20.168
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change 0.0203
Regular Market Change Percent 3.18381
Regular Market Day High 0.6919
Regular Market Day Low 0.635
Regular Market Day Range 0.635 - 0.6919
Regular Market Open 0.635
Regular Market Previous Close 0.6376
Regular Market Price 0.6579
Regular Market Time 1,783,972,800
Regular Market Volume 2,889,338
Return On Assets -0.37013
Return On Equity -0.63162
Revenue Growth -0.574
Revenue Per Share 0.011
Sand P52 Week Change 0.20847368
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 33,385,055
Shares Percent Shares Out 0.0031
Shares Short 104,336
Shares Short Previous Month Date 1,780,012,800
Shares Short Prior Month 120,420
Short Name VYNE Therapeutics Inc.
Short Percent Of Float 0.0032
Short Ratio 0.89
Source Interval 15
State NJ
Symbol VYNE
Total Cash 24,928,000
Total Cash Per Share 0.747
Total Debt 0
Total Revenue 454,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -0.53
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 0.540595
Two Hundred Day Average Change 0.11730498
Two Hundred Day Average Change Percent 0.21699235
Type Disp Equity
Volume 2,889,338
Website https://vynetherapeutics.com
Zip 8,886