Tyra Biosciences, Inc. (TYRA)Healthcare | Biotechnology | Carlsbad, United States | NasdaqGS
26.99 USD
+1.42
(5.553%)
⇧
(June 12, 2026, 4 p.m.
EDT)
After hours: 26.99 |
Hot Take ↕ | June 7, 2026, 4:47 a.m. EDT
The investment case for Tyra Biosciences is currently fractured by a stark disconnect between optimistic analyst targets and deteriorating operational reality. While the balance sheet appears pristine with negligible debt and massive liquidity, the company is burning significant cash, resulting in negative free cash flow and double-digit losses on both assets and equity. The stock has already punished investors with a sharp decline in the trailing twelve months, erasing nearly half its value despite a positive cumulative gain over the last three years. Crucially, there is no dividend to provide a floor, and the recent price action shows a clear downward trend, breaking below key moving averages. Although the forward P/E is technically negative due to losses, the lack of profitability and the heavy put positioning by traders suggest the market is pricing in further struggles before any catalyst can drive a recovery. The 'strong buy' analyst consensus seems to rely on a future drug approval that has not yet materialized, creating a dangerous gap between narrative and current performance. |
| Model | MAE |
|---|---|
| MSTL ✓ | 0.059275 |
| AutoARIMA | 0.062195 |
| AutoETS | 0.062205 |
| AutoTheta | 0.066085 |
| MSTL_119 | 0.076357 |
| MSTL_79 | 0.114927 |
| MSTL_79_119 | 0.125102 |
Forecast horizon: 60 days | Selected: MSTL
| Forecast Reliability | |
|---|---|
| Score | 22% |
| H-stat | 9.24 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.000 |
| Excess Kurtosis | 2.66 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 1.47 |
| Market Cap | 1,605,105,536 |
| Forward P/E | -9.55 |
| Beta | 0.75 |
| Website | https://tyra.bio |
As of June 7, 2026, 4:47 a.m. EDT: Speculators are heavily positioned for downside protection, with massive open interest in June and July puts concentrated at the $30 strike, while call activity remains sparse and skewed toward distant out-of-the-money strikes. This asymmetry suggests a market expectation of continued volatility or a drop below current levels rather than an imminent rally.
| Attribute | Value |
|---|---|
| 52 Week Change | 1.6409001 |
| Address1 | 2,656 State Street |
| All Time High | 40.65 |
| All Time Low | 4.93 |
| Ask | 32.71 |
| Ask Size | 2 |
| Audit Risk | 5 |
| Average Analyst Rating | 1.3 - Strong Buy |
| Average Daily Volume10 Day | 1,095,850 |
| Average Daily Volume3 Month | 959,160 |
| Average Volume | 959,160 |
| Average Volume10Days | 1,095,850 |
| Beta | 0.754 |
| Bid | 19.44 |
| Bid Size | 2 |
| Board Risk | 7 |
| Book Value | 4.826 |
| City | Carlsbad |
| Compensation As Of Epoch Date | 1,767,139,200 |
| Compensation Risk | 9 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 26.99 |
| Current Ratio | 20.493 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,780,012,800 |
| Day High | 27.58 |
| Day Low | 25.0076 |
| Debt To Equity | 1.47 |
| Earnings Timestamp | 1,778,675,400 |
| Earnings Timestamp End | 1,786,624,200 |
| Earnings Timestamp Start | 1,786,624,200 |
| Ebitda | -142,368,992 |
| Ebitda Margins | 0.0 |
| Enterprise To Ebitda | -8.621 |
| Enterprise Value | 1,227,336,576 |
| Eps Current Year | -2.5715 |
| Eps Forward | -2.82564 |
| Eps Trailing Twelve Months | -2.18 |
| Esg Populated | 0 |
| Exchange | NMS |
| Exchange Data Delayed By | 0 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fifty Day Average | 33.6251 |
| Fifty Day Average Change | -6.6350994 |
| Fifty Day Average Change Percent | -0.1973258 |
| Fifty Two Week Change Percent | 164.09001 |
| Fifty Two Week High | 40.65 |
| Fifty Two Week High Change | -13.660002 |
| Fifty Two Week High Change Percent | -0.3360394 |
| Fifty Two Week Low | 8.98 |
| Fifty Two Week Low Change | 18.01 |
| Fifty Two Week Low Change Percent | 2.005568 |
| Fifty Two Week Range | 8.98 - 40.65 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,631,712,600,000 |
| Float Shares | 30,882,969 |
| Forward Eps | -2.82564 |
| Forward P E | -9.551819 |
| Free Cashflow | -60,137,752 |
| Full Exchange Name | NasdaqGS |
| Full Time Employees | 87 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Governance Epoch Date | 1,780,531,200 |
| Gross Margins | 0.0 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.0286 |
| Held Percent Institutions | 1.11516 |
| Implied Shares Outstanding | 59,470,381 |
| Industry | Biotechnology |
| Industry Disp | Biotechnology |
| Industry Key | biotechnology |
| Ipo Expected Date | 2,021-09-15 |
| Is Earnings Date Estimate | 1 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Long Business Summary | Tyra Biosciences, Inc., a clinical-stage biotechnology company, develops precision medicines for fibroblast growth factor receptor (FGFR) biology in the United States. The company offers SNÅP, a precision medicine platform that enables drug design through iterative molecular snapshots to predict genetic alterations for developing therapies targeting oncology and genetically defined conditions. Its lead product candidate is FGFR3, which is in clinical trials for the treatment of patients with metastatic urothelial carcinoma and other solid tumors. The company is also developing TYRA-300 for skeletal conditions, including achondroplasia, hypochondroplasia, dysplasia, and other FGFR3-driven genetic syndromes; TYRA-200, a candidate in clinical trial for intrahepatic cholangiocarcinoma; and TYRA-430 for the treatment of hepatocellular carcinoma. Tyra Biosciences, Inc. was incorporated in 2018 and is headquartered in Carlsbad, California. |
| Long Name | Tyra Biosciences, Inc. |
| Market | us_market |
| Market Cap | 1,605,105,536 |
| Market State | POSTPOST |
| Max Age | 86,400 |
| Message Board Id | finmb_650787124 |
| Most Recent Quarter | 1,774,915,200 |
| Net Income To Common | -131,105,000 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 1,605,105,583 |
| Number Of Analyst Opinions | 11 |
| Open | 25.64 |
| Operating Cashflow | -102,255,000 |
| Operating Margins | 0.0 |
| Overall Risk | 8 |
| Payout Ratio | 0.0 |
| Phone | 619 728 4760 |
| Post Market Change | 0.0 |
| Post Market Change Percent | 0.0 |
| Post Market Price | 26.99 |
| Post Market Time | 1,781,295,005 |
| Previous Close | 25.57 |
| Price Eps Current Year | -10.495819 |
| Price Hint | 2 |
| Price To Book | 5.592623 |
| Profit Margins | 0.0 |
| Quick Ratio | 20.054 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | strong_buy |
| Recommendation Mean | 1.28571 |
| Region | US |
| Regular Market Change | 1.42 |
| Regular Market Change Percent | 5.55338 |
| Regular Market Day High | 27.58 |
| Regular Market Day Low | 25.0076 |
| Regular Market Day Range | 25.0076 - 27.58 |
| Regular Market Open | 25.64 |
| Regular Market Previous Close | 25.57 |
| Regular Market Price | 26.99 |
| Regular Market Time | 1,781,294,400 |
| Regular Market Volume | 1,012,919 |
| Return On Assets | -0.23643999 |
| Return On Equity | -0.36873 |
| Sand P52 Week Change | 0.23177934 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Share Holder Rights Risk | 8 |
| Shares Outstanding | 59,470,381 |
| Shares Percent Shares Out | 0.15609999 |
| Shares Short | 9,281,430 |
| Shares Short Previous Month Date | 1,777,507,200 |
| Shares Short Prior Month | 7,708,671 |
| Short Name | Tyra Biosciences, Inc. |
| Short Percent Of Float | 0.2885 |
| Short Ratio | 12.54 |
| Source Interval | 15 |
| State | CA |
| Symbol | TYRA |
| Target High Price | 59.62 |
| Target Low Price | 42.0 |
| Target Mean Price | 51.60182 |
| Target Median Price | 53.0 |
| Total Cash | 383,465,984 |
| Total Cash Per Share | 6.448 |
| Total Debt | 5,697,000 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -2.18 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 25.85685 |
| Two Hundred Day Average Change | 1.1331501 |
| Two Hundred Day Average Change Percent | 0.04382398 |
| Type Disp | Equity |
| Volume | 1,012,919 |
| Website | https://tyra.bio |
| Zip | 92,008 |