Talphera, Inc. (TLPH)Healthcare | Drug Manufacturers - Specialty & Generic | San Mateo, United States | NasdaqCM
1.07 USD
-0.01
(-0.926%) ⇩
(Oct. 13, 2026, 4 p.m.
EDT)
|
Hot Take ↕ | Oct. 10, 2026, 6:25 a.m. EDT
The investment case for Talphera is currently broken by a catastrophic multi-year decline. Despite a recent year-over-year price recovery, the stock has lost over 98% of its value since 2016, a trend driven by six consecutive years of negative annual returns. This structural deterioration, evidenced by a massive drop in book value and negative operating margins, suggests the market has correctly identified a failing business model rather than a temporary dislocation. The absence of any dividend payments further erodes total return potential. While insider buying and a new analyst buy rating offer a glimmer of hope, they cannot override the fundamental reality of a company with negative free cash flow and a balance sheet that has shrunk precipitously. The options market confirms this pessimism, with traders stacking puts at key support levels while ignoring near-term upside. Until the core business demonstrates sustained profitability and a reversal in the long-term capital destruction trend, this remains a high-risk speculative vehicle unsuitable for serious capital allocation. |
| Model | MAE |
|---|---|
| MSTL ✓ | 0.060649 |
| AutoARIMA | 0.063245 |
| AutoETS | 0.063247 |
| AutoTheta | 0.286593 |
Forecast horizon: 45 days | Selected: MSTL
| Forecast Reliability | |
|---|---|
| Score | 41% |
| H-stat | 1.21 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.098 |
| Excess Kurtosis | -0.51 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 45.113 |
| Market Cap | 55,539,204 |
| Forward P/E | -4.79 |
| Beta | 0.68 |
| Previous Name | AcelRx Pharmaceuticals, Inc. |
| Website | https://talphera.com |
As of Oct. 10, 2026, 6:25 a.m. EDT: Speculators are heavily positioned for downside protection, with put volume significantly outweighing call volume. The 'Top OI' for puts sits at the $1.50 strike, creating a dense wall of resistance just above current prices. Conversely, call interest is sparse and skewed toward deep out-of-the-money strikes ($2.50 and $7.50), indicating a lack of near-term bullish conviction.
| Attribute | Value |
|---|---|
| 52 Week Change | -0.036036015 |
| Address1 | 1,850 Gateway Drive |
| Address2 | Suite 175 |
| All Time High | 272.8 |
| All Time Low | 0.38 |
| Ask | 1.08 |
| Ask Size | 2 |
| Average Daily Volume10 Day | 187,740 |
| Average Daily Volume3 Month | 209,007 |
| Average Volume | 209,007 |
| Average Volume10Days | 187,740 |
| Beta | 0.675 |
| Bid | 1.18 |
| Bid Size | 8 |
| Book Value | 0.278 |
| City | San Mateo |
| Compensation As Of Epoch Date | 1,767,139,200 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 1.07 |
| Current Ratio | 4.295 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,790,726,400 |
| Day High | 1.08 |
| Day Low | 1.055 |
| Debt To Equity | 45.113 |
| Display Name | Talphera |
| Dividend Yield | 0.0 |
| Earnings Call Timestamp End | 1,786,566,600 |
| Earnings Call Timestamp Start | 1,786,566,600 |
| Earnings Timestamp | 1,786,564,800 |
| Earnings Timestamp End | 1,794,427,200 |
| Earnings Timestamp Start | 1,794,427,200 |
| Ebitda Margins | 0.0 |
| Enterprise To Revenue | 44,962.203 |
| Enterprise Value | 44,962,200 |
| Eps Current Year | -0.205 |
| Eps Forward | -0.22333 |
| Eps Trailing Twelve Months | -0.26 |
| Esg Populated | 0 |
| Exchange | NCM |
| Exchange Data Delayed By | 15 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fifty Day Average | 1.2088 |
| Fifty Day Average Change | -0.1387999 |
| Fifty Day Average Change Percent | -0.11482455 |
| Fifty Two Week Change Percent | -3.6036015 |
| Fifty Two Week High | 1.57 |
| Fifty Two Week High Change | -0.5 |
| Fifty Two Week High Change Percent | -0.3184713 |
| Fifty Two Week Low | 0.69 |
| Fifty Two Week Low Change | 0.38000005 |
| Fifty Two Week Low Change Percent | 0.55072474 |
| Fifty Two Week Range | 0.69 - 1.57 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,297,434,600,000 |
| Float Shares | 25,230,888 |
| Forward Eps | -0.22333 |
| Forward P E | -4.791116 |
| Free Cashflow | -6,870,875 |
| Full Exchange Name | NasdaqCM |
| Full Time Employees | 12 |
| Fullday Change | -0.00999999 |
| Fullday Change Percent | -0.9345786 |
| Fullday Price | 1.07 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Gross Margins | 0.0 |
| Gross Profits | -6,703,000 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.21413 |
| Held Percent Institutions | 0.46071 |
| Implied Shares Outstanding | 51,905,796 |
| Industry | Drug Manufacturers - Specialty & Generic |
| Industry Disp | Drug Manufacturers - Specialty & Generic |
| Industry Key | drug-manufacturers-specialty-generic |
| Is Earnings Date Estimate | 0 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Last Split Date | 1,666,742,400 |
| Last Split Factor | 1:20 |
| Long Business Summary | Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit. It is also developing LTX-608, a lyophilized vial containing nafamostat for IV infusion for disseminated intravascular coagulation, acute respiratory distress syndrome, acute pancreatitis, and an anti-viral treatment; Fedsyra, an ephedrine pre-filled syringe for injection; and a phenylephrine pre-filled syringe for injection. The company was formerly known as AcelRx Pharmaceuticals, Inc. and changed its name to Talphera, Inc. in January 2024. The company was incorporated in 2005 and is headquartered in San Mateo, California. |
| Long Name | Talphera, Inc. |
| Market | us_market |
| Market Cap | 55,539,204 |
| Market State | PRE |
| Max Age | 86,400 |
| Message Board Id | finmb_33172220 |
| Most Recent Quarter | 1,782,777,600 |
| Name Change Date | 2,026-10-14 |
| Net Income To Common | -15,076,000 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 60,470,252 |
| Number Of Analyst Opinions | 4 |
| Open | 1.08 |
| Operating Cashflow | -12,270,000 |
| Operating Margins | -14,747.0 |
| Payout Ratio | 0.0 |
| Phone | 650 216 3500 |
| Prev Name | AcelRx Pharmaceuticals, Inc. |
| Previous Close | 1.08 |
| Price Eps Current Year | -5.2195125 |
| Price Hint | 4 |
| Price To Book | 3.848921 |
| Price To Sales Trailing12 Months | 55,539.203 |
| Profit Margins | 0.0 |
| Quick Ratio | 4.077 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | none |
| Region | US |
| Regular Market Change | -0.00999999 |
| Regular Market Change Percent | -0.925925 |
| Regular Market Day High | 1.08 |
| Regular Market Day Low | 1.055 |
| Regular Market Day Range | 1.055 - 1.08 |
| Regular Market Open | 1.08 |
| Regular Market Previous Close | 1.08 |
| Regular Market Price | 1.07 |
| Regular Market Time | 1,791,921,600 |
| Regular Market Volume | 62,821 |
| Return On Assets | -0.42551997 |
| Return On Equity | -1.43356 |
| Revenue Per Share | 0.0 |
| Sand P52 Week Change | 0.17004645 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Shares Outstanding | 51,905,796 |
| Shares Percent Shares Out | 0.0139 |
| Shares Short | 721,534 |
| Shares Short Previous Month Date | 1,788,134,400 |
| Shares Short Prior Month | 508,627 |
| Short Name | Talphera, Inc. |
| Short Percent Of Float | 0.0171 |
| Short Ratio | 6.57 |
| Source Interval | 15 |
| State | CA |
| Symbol | TLPH |
| Target High Price | 3.5 |
| Target Low Price | 3.0 |
| Target Mean Price | 3.125 |
| Target Median Price | 3.0 |
| Total Cash | 17,076,000 |
| Total Cash Per Share | 0.329 |
| Total Debt | 6,499,000 |
| Total Revenue | 1,000 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -0.26 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 1.01445 |
| Two Hundred Day Average Change | 0.0555501 |
| Two Hundred Day Average Change Percent | 0.054758836 |
| Type Disp | Equity |
| Volume | 62,821 |
| Website | https://talphera.com |
| Zip | 94,404 |