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Rapport Therapeutics, Inc. (RAPP)

Healthcare | Biotechnology | Boston, United States | NasdaqGM
48.77 USD -2.06 (-4.053%) ⇩ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 48.77

Short-term:★★⯪☆☆Long-term:★☆☆☆☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 1:44 a.m. EDT

The investment case for Rapport Therapeutics is currently defined by a stark disconnect between optimistic analyst sentiment and deteriorating market reality. While analysts maintain a 'strong buy' rating and raised price targets, the stock has suffered a crushing 30% decline over the last year, dragging the price down from $21 to under $15 before a recent, fragile recovery. Fundamentally, the company is in distress: it reports negative gross margins, negative operating cash flow, and a forward P/E that implies continued losses. There is no dividend to cushion the blow, and the balance sheet shows significant free cash burn. The most critical signal here is the options flow. The market is screaming 'sell' or 'hedge,' with traders accumulating thousands of contracts in deep out-of-the-money puts while leaving the call side virtually empty. This aggressive put buying indicates that investors fear a continuation of the downtrend or a failed clinical trial, despite the hype around Phase 3 progress. The statistical forecast model offers only a weak, low-confidence lean upward, which is insufficient to counter the overwhelming bearish positioning in derivatives. For the short term, the stock is hovering near resistance after a volatile bounce, but the lack of genuine bullish options flow and the heavy put wall suggest any further upside is likely to be capped until the underlying business fundamentals turn positive. For the long term, the combination of negative margins, cash burn, and a multi-year price decline makes this a high-risk speculative play rather than a solid buy. The market appears to be pricing in a value trap where the current price does not reflect the severity of the operational challenges.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoTheta ✓0.072508
MSTL0.082206
AutoARIMA0.086405
AutoETS0.090890

Forecast horizon: 45 days | Selected: AutoTheta

Forecast Reliability
Score 31%
H-stat 8.95
Ljung-Box p 0.000
Jarque-Bera p 0.907
Excess Kurtosis 0.20
Attribute Value
Sector Healthcare
Debt to Equity Ratio 2.389
Revenue per Share 0.445
Market Cap 2,339,901,184
Forward P/E -9.33
Beta 0.97
Website https://www.rapportrx.com

As of Aug. 22, 2026, 1:44 a.m. EDT: Speculators are heavily positioning for downside protection, evidenced by massive open interest in out-of-the-money puts (strikes $25-$40) expiring late in 2026 and early 2027, while call activity remains negligible outside of immediate ATM anchors. This distribution suggests a market consensus expecting significant volatility or a drop in share price rather than a rally.


Info Dump

Attribute Value
52 Week Change 2.1050704
Address1 99 High Street
Address2 Suite 2100
All Time High 52.93
All Time Low 6.43
Ask 52.54
Ask Size 2
Audit Risk 5
Average Analyst Rating 1.1 - Strong Buy
Average Daily Volume10 Day 262,330
Average Daily Volume3 Month 354,716
Average Volume 354,716
Average Volume10Days 262,330
Beta 0.971
Bid 30.56
Bid Size 2
Board Risk 6
Book Value 8.819
City Boston
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 9
Country United States
Crypto Tradeable 0
Currency USD
Current Price 48.77
Current Ratio 15.721
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 50.6751
Day Low 48.37
Debt To Equity 2.389
Display Name Rapport Therapeutics
Earnings Timestamp 1,785,933,000
Earnings Timestamp End 1,793,881,800
Earnings Timestamp Start 1,793,881,800
Ebitda -152,556,000
Ebitda Margins 0.0
Enterprise To Ebitda -12.546
Enterprise To Revenue 95.696
Enterprise Value 1,913,928,960
Eps Current Year -4.09333
Eps Forward -5.22889
Eps Trailing Twelve Months -3.03
Esg Populated 0
Exchange NGM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 43.1285
Fifty Day Average Change 5.6414986
Fifty Day Average Change Percent 0.13080673
Fifty Two Week Change Percent 210.50703
Fifty Two Week High 52.93
Fifty Two Week High Change -4.16
Fifty Two Week High Change Percent -0.078594364
Fifty Two Week Low 14.11
Fifty Two Week Low Change 34.66
Fifty Two Week Low Change Percent 2.456414
Fifty Two Week Range 14.11 - 52.93
Financial Currency USD
First Trade Date Milliseconds 1,717,767,000,000
Float Shares 32,304,740
Forward Eps -5.22889
Forward P E -9.327027
Free Cashflow -56,016,500
Full Exchange Name NasdaqGM
Full Time Employees 84
Fullday Change -2.06
Fullday Change Percent -4.05273
Fullday Price 48.77
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,785,542,400
Gross Margins -1.0939
Gross Profits -21,878,000
Has Pre Post Market Data 1
Held Percent Insiders 0.0392
Held Percent Institutions 1.0871
Implied Shares Outstanding 47,978,286
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,024-06-07
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Rapport Therapeutics, Inc., operates as a clinical-stage biopharmaceutical company that focuses on the discovery and development of transformational small molecule medicines for patients suffering from central nervous system (CNS) disorders. The company's lead product candidate is receptor associated protein (RAP)-219, an investigational small molecule that is designed to inhibit TARPy8-containing AMPARs with picomolar affinity for the treatment of focal epilepsy and other CNS disorders, including peripheral neuropathic pain and bipolar disorder. It also develops nicotinic acetylcholine receptor (nAChR) programs, such as a6 nAChR to treat chronic pain and migraine; and a9a10 nAChR for the treatment of hearing/vestibular disorders. The company was formerly known as Precision Neuroscience NewCo, Inc. and changed its name to Rapport Therapeutics, Inc. in October 2022. Rapport Therapeutics, Inc. was incorporated in 2022 and is headquartered in Boston, Massachusetts.
Long Name Rapport Therapeutics, Inc.
Market us_market
Market Cap 2,339,901,184
Market State CLOSED
Max Age 86,400
Message Board Id finmb_1828746377
Most Recent Quarter 1,782,777,600
Net Income To Common -137,160,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 2,438,736,277
Number Of Analyst Opinions 12
Open 50.0
Operating Cashflow -96,682,000
Operating Margins -7.6758003
Overall Risk 7
Payout Ratio 0.0
Phone 857 321 8020
Post Market Change 0.0
Post Market Change Percent 0.0
Post Market Price 48.77
Post Market Time 1,787,959,806
Previous Close 50.83
Price Eps Current Year -11.914505
Price Hint 2
Price To Book 5.5301056
Price To Sales Trailing12 Months 116.995056
Profit Margins 0.0
Quick Ratio 15.352
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.07692
Region US
Regular Market Change -2.06
Regular Market Change Percent -4.05273
Regular Market Day High 50.6751
Regular Market Day Low 48.37
Regular Market Day Range 48.37 - 50.6751
Regular Market Open 50.0
Regular Market Previous Close 50.83
Regular Market Price 48.77
Regular Market Time 1,787,947,200
Regular Market Volume 332,729
Return On Assets -0.25776
Return On Equity -0.39963
Revenue Per Share 0.445
Sand P52 Week Change 0.20504117
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 8
Shares Outstanding 47,978,286
Shares Percent Shares Out 0.0464
Shares Short 2,225,618
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 2,690,734
Short Name Rapport Therapeutics, Inc.
Short Percent Of Float 0.0734
Short Ratio 7.33
Source Interval 15
State MA
Symbol RAPP
Target High Price 80.0
Target Low Price 50.0
Target Mean Price 62.04833
Target Median Price 59.0
Total Cash 436,076,992
Total Cash Per Share 9.089
Total Debt 10,105,000
Total Revenue 20,000,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -3.03
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 34.11645
Two Hundred Day Average Change 14.653549
Two Hundred Day Average Change Percent 0.42951563
Type Disp Equity
Volume 332,729
Website https://www.rapportrx.com
Zip 2,110