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Protalix BioTherapeutics, Inc. (PLX)

Healthcare | Biotechnology | Hackensack, United States | NYSE American
2.54 USD -0.07 (-2.682%) ⇩ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 2.58 +0.04 (1.673%) ⇧ (Aug. 28, 2026, 5:25 p.m. EDT)

Short-term:★★⯪☆☆Long-term:★★⯪☆☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 3:15 a.m. EDT

The narrative here is a classic biotech divergence: explosive top-line growth masking a precarious balance sheet. The company delivered a staggering 234% revenue surge in the first quarter, pushing earnings growth to 22%, which explains the aggressive analyst upgrades and the 'strong buy' consensus. Fundamentally, the business is printing money relative to its size, with healthy margins and a forward P/E that looks cheap compared to the growth rate. However, the long-term outlook remains murky due to the company's history. Over the last nine years, the stock has been a brutal drawdown, losing roughly 74% of its value. While the most recent annual period saw a rebound, the legacy of six consecutive years of negative returns creates a deep skepticism about whether this latest success is sustainable or just a temporary blip. The market hasn't fully priced in the recovery yet, but the path is fraught with execution risk. For the short term, the options market tells a story of uncertainty. Traders are buying deep out-of-the-money calls, hoping for a moonshot, while simultaneously hedging with puts. This indicates a lack of conviction in a steady grind higher. With no dividend to provide a floor and a history of volatile price action, this is not a buy-and-hold candidate. It is a high-risk, high-reward speculative play dependent on the company successfully navigating its clinical trials and commercialization hurdles. The current price sits in a precarious spot where a single missed milestone could erase the gains from the recent revenue explosion.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.047705
AutoTheta0.066667
AutoETS0.067685
AutoARIMA0.125358

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 38%
H-stat 3.57
Ljung-Box p 0.006
Jarque-Bera p 0.016
Excess Kurtosis 0.73
Attribute Value
Sector Healthcare
Debt to Equity Ratio 12.894
Revenue per Share 1.012
Market Cap 204,651,968
Trailing P/E 11.55
Forward P/E 4.10
Beta 0.01
Profit Margins 23.50%
Website https://www.protalix.com

As of Aug. 22, 2026, 3:15 a.m. EDT: Speculators are positioning for significant volatility rather than a specific directional breakout. Call volume is heavily skewed toward out-of-the-money strikes (5.0) with massive open interest, suggesting a speculative bet on a massive rally or binary event. However, put open interest is concentrated at lower strikes (2.0), creating a 'straddle' environment where traders are betting on a wide range of movement rather than a clean trend. The lack of in-the-money call volume suggests the market does not currently believe the stock will sustainably trade above current levels without a catalyst.


Info Dump

Attribute Value
52 Week Change 0.59146345
Address1 2 University Plaza
Address2 Suite 100
All Time High 912.5
All Time Low 0.7
Ask 2.56
Ask Size 900
Audit Risk 8
Average Daily Volume10 Day 708,510
Average Daily Volume3 Month 680,966
Average Volume 680,966
Average Volume10Days 708,510
Beta 0.012
Bid 2.55
Bid Size 1,400
Board Risk 7
Book Value 0.834
City Hackensack
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 8
Country United States
Crypto Tradeable 0
Currency USD
Current Price 2.54
Current Ratio 2.938
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 2.62
Day Low 2.53
Debt To Equity 12.894
Display Name Protalix BioTherapeutics
Dividend Date 1,576,800,000
Earnings Call Timestamp End 1,786,536,000
Earnings Call Timestamp Start 1,786,536,000
Earnings Growth 22.411
Earnings Quarterly Growth 22.03
Earnings Timestamp 1,786,537,800
Earnings Timestamp End 1,794,486,600
Earnings Timestamp Start 1,794,486,600
Ebitda 24,860,000
Ebitda Margins 0.30836
Enterprise To Ebitda 6.967
Enterprise To Revenue 2.148
Enterprise Value 173,202,976
Eps Forward 0.62
Eps Trailing Twelve Months 0.22
Esg Populated 0
Exchange ASE
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 2.35
Fifty Day Average Change 0.19000006
Fifty Day Average Change Percent 0.08085109
Fifty Two Week Change Percent 59.146343
Fifty Two Week High 3.19
Fifty Two Week High Change -0.6500001
Fifty Two Week High Change Percent -0.20376179
Fifty Two Week Low 1.52
Fifty Two Week Low Change 1.02
Fifty Two Week Low Change Percent 0.67105263
Fifty Two Week Range 1.52 - 3.19
Financial Currency USD
First Trade Date Milliseconds 895,239,000,000
Float Shares 77,447,074
Forward Eps 0.62
Forward P E 4.096774
Free Cashflow 2,992,375
Full Exchange Name NYSE American
Full Time Employees 226
Fullday Change -0.0699999
Fullday Change Percent -2.68199
Fullday Price 2.5825
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,785,542,400
Gross Margins 0.45768002
Gross Profits 36,898,000
Has Pre Post Market Data 1
Held Percent Insiders 0.03878
Held Percent Institutions 0.18355
Implied Shares Outstanding 80,571,642
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,576,800,000
Last Split Factor 1:10
Long Business Summary Protalix BioTherapeutics, Inc., a biopharmaceutical company, engages in the development, production, and commercialization of recombinant therapeutic proteins based on the ProCellEx plant cell-based protein expression system. The company provides Elelyso for the treatment of Gaucher disease; and Elfabrio for the treatment of adult patients with a confirmed diagnosis of Fabry disease. It is also developing PRX-115, a plant cell expressed recombinant PEGylated Uricase, which is in Phase 2 trial for the treatment of gout; and PRX-119, a plant cell expressed PEGylated recombinant human DNase I product candidate for the treatment of neutrophil extracellular traps diseases. The company has agreements and partnerships with Pfizer; Fundação Oswaldo Cruz; and Chiesi Farmaceutici S.p.A. Protalix BioTherapeutics, Inc. has strategic partnership with Secarna Pharmaceuticals GmbH & Co KG. The company is headquartered in Hackensack. New Jersey.
Long Name Protalix BioTherapeutics, Inc.
Market us_market
Market Cap 204,651,968
Market State CLOSED
Max Age 86,400
Message Board Id finmb_941520
Most Recent Quarter 1,782,777,600
Net Income To Common 18,945,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 210,291,985
Number Of Analyst Opinions 2
Open 2.61
Operating Cashflow 9,923,000
Operating Margins 0.23482001
Overall Risk 6
Payout Ratio 0.0
Phone 201 696 9345
Post Market Change 0.04250002
Post Market Change Percent 1.6732291
Post Market Price 2.5825
Post Market Time 1,787,952,349
Previous Close 2.61
Price Hint 4
Price To Book 3.0455635
Price To Sales Trailing12 Months 2.538508
Profit Margins 0.23499
Quick Ratio 1.821
Quote Source Name Delayed Quote
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change -0.0699999
Regular Market Change Percent -2.68199
Regular Market Day High 2.62
Regular Market Day Low 2.53
Regular Market Day Range 2.53 - 2.62
Regular Market Open 2.61
Regular Market Previous Close 2.61
Regular Market Price 2.54
Regular Market Time 1,787,947,200
Regular Market Volume 490,162
Return On Assets 0.15419
Return On Equity 0.31235
Revenue Growth 0.271
Revenue Per Share 1.012
Sand P52 Week Change 0.20504117
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 3
Shares Outstanding 80,571,642
Shares Percent Shares Out 0.0444
Shares Short 3,576,201
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 3,715,907
Short Name Protalix BioTherapeutics, Inc.
Short Percent Of Float 0.0462
Short Ratio 4.97
Source Interval 15
State NJ
Symbol PLX
Target High Price 12.0
Target Low Price 10.0
Target Mean Price 11.0
Target Median Price 11.0
Total Cash 40,656,000
Total Cash Per Share 0.505
Total Debt 9,207,000
Total Revenue 80,619,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps 0.22
Trailing P E 11.545454
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 2.2265
Two Hundred Day Average Change 0.31349993
Two Hundred Day Average Change Percent 0.14080392
Type Disp Equity
Volume 490,162
Website https://www.protalix.com
Zip 7,601