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Palisade Bio, Inc. (PALI)

Healthcare | Biotechnology | Denver, United States | NasdaqCM
1.59 USD +0.05 (3.247%) ⇧ (Oct. 12, 2026, 4 p.m. EDT)

Short-term:★★☆☆☆Long-term:⯪☆☆☆☆Dividends:☆☆☆☆☆
Hot Take ↕ | Oct. 10, 2026, 4:21 a.m. EDT

The investment case here is structurally broken. While analysts project a massive recovery to $10, the market has already priced in a decade of catastrophic failure, evidenced by nine consecutive years of negative annual returns and a cumulative loss of nearly 100% over the observation window. This is not a temporary setback; the price history confirms a long-term structural deterioration where the market has repeatedly rejected the business model. Fundamentally, the company is burning cash aggressively with negative operating margins and no revenue generation, while the balance sheet shows significant liabilities relative to its tiny market cap. The recent price action shows the stock hovering near its 52-week lows, failing to break out of its downtrend despite some recent buying interest. With no dividend to provide income and a high short interest suggesting skepticism among leveraged players, the risk-reward profile remains severely skewed against the buyer until the clinical pipeline proves definitive results that can reverse this multi-year decline.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.077484
AutoTheta0.078819
AutoETS0.078836
AutoARIMA0.089009

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 29%
H-stat 9.78
Ljung-Box p 0.000
Jarque-Bera p 0.001
Excess Kurtosis 0.57
Attribute Value
Sector Healthcare
Revenue per Share 0.003
Market Cap 277,090,208
Trailing P/E 2.65
Forward P/E -5.60
Beta 1.62
Previous Name Seneca Biopharma, Inc.
Website https://www.palisadebio.com

Info Dump

Attribute Value
52 Week Change -0.14054054
Address1 4,600 South Syracuse Street
Address2 Suite 900
All Time High 5,627,700.0
All Time Low 0.53
Ask 1.95
Ask Size 2
Audit Risk 10
Average Analyst Rating 1.3 - Strong Buy
Average Daily Volume10 Day 2,145,700
Average Daily Volume3 Month 2,508,979
Average Volume 2,508,979
Average Volume10Days 2,145,700
Beta 1.62
Bid 1.17
Bid Size 2
Board Risk 7
Book Value 0.701
City Denver
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 10
Country United States
Crypto Tradeable 0
Currency USD
Current Price 1.59
Current Ratio 24.258
Custom Price Alert Confidence HIGH
Date Short Interest 1,790,726,400
Day High 1.63
Day Low 1.51
Display Name Palisade Bio
Dividend Date 1,563,408,000
Dividend Yield 0.0
Earnings Timestamp End 1,755,288,000
Earnings Timestamp Start 1,754,942,400
Ebitda -35,346,500
Ebitda Margins 0.0
Enterprise To Ebitda -4.298
Enterprise To Revenue 303.84
Enterprise Value 151,920,192
Eps Current Year -0.22375
Eps Forward -0.28375
Eps Trailing Twelve Months 0.6
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 15
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 1.8648
Fifty Day Average Change -0.27479994
Fifty Day Average Change Percent -0.14736162
Fifty Two Week Change Percent -14.054054
Fifty Two Week High 2.86
Fifty Two Week High Change -1.2699999
Fifty Two Week High Change Percent -0.4440559
Fifty Two Week Low 1.32
Fifty Two Week Low Change 0.26999998
Fifty Two Week Low Change Percent 0.20454544
Fifty Two Week Range 1.32 - 2.86
Financial Currency USD
First Trade Date Milliseconds 1,175,261,400,000
Float Shares 135,425,651
Forward Eps -0.28375
Forward P E -5.603524
Free Cashflow -8,654,125
Full Exchange Name NasdaqCM
Full Time Employees 14
Fullday Change 0.05000007
Fullday Change Percent 3.246758
Fullday Price 1.59
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,790,812,800
Gross Margins 1.0
Gross Profits 500,000
Has Pre Post Market Data 1
Held Percent Insiders 0.04156
Held Percent Institutions 1.01348
Implied Shares Outstanding 174,270,558
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,712,534,400
Last Split Factor 1:15
Long Business Summary Palisade Bio, Inc., a clinical-stage biopharmaceutical company, engages in developing oral phosphodiesterase-4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon in the United States. Its lead clinical product candidate includes PALI-2108, which is in phase 1b clinical trial to treat patients with inflammatory bowel disease, including ulcerative colitis and Fibrostenotic Crohn's disease. The company has a research collaboration and license agreement with Giiant Pharma, Inc. for the development, manufacture, and commercialization of its compounds; license agreement with the Regents of the University of California for sole purpose of maintaining the Newsoara Co-Development; and a co-development and distribution agreement with Newsoara Biopharma Co., Ltd. The company was founded in 2001 and is headquartered in Denver, Colorado.
Long Name Palisade Bio, Inc.
Market us_market
Market Cap 277,090,208
Market State PRE
Max Age 86,400
Message Board Id finmb_244367385
Most Recent Quarter 1,782,777,600
Name Change Date 2,026-10-13
Net Income To Common -31,941,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 281,769,951
Number Of Analyst Opinions 10
Open 1.5253
Operating Cashflow -18,190,000
Operating Margins -23.396002
Overall Risk 10
Payout Ratio 0.0
Phone 858 704 4900
Prev Name Seneca Biopharma, Inc.
Previous Close 1.54
Price Eps Current Year -7.1061454
Price Hint 4
Price To Book 2.2681885
Price To Sales Trailing12 Months 554.1804
Profit Margins 0.0
Quick Ratio 23.956
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.3
Region US
Regular Market Change 0.0500001
Regular Market Change Percent 3.24676
Regular Market Day High 1.63
Regular Market Day Low 1.51
Regular Market Day Range 1.51 - 1.63
Regular Market Open 1.5253
Regular Market Previous Close 1.54
Regular Market Price 1.59
Regular Market Time 1,791,835,200
Regular Market Volume 1,571,663
Return On Assets -0.32979
Return On Equity -0.51365
Revenue Per Share 0.003
Sand P52 Week Change 0.17502642
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 9
Shares Outstanding 174,270,558
Shares Percent Shares Out 0.17799999
Shares Short 31,015,282
Shares Short Previous Month Date 1,788,134,400
Shares Short Prior Month 30,902,111
Short Name Palisade Bio, Inc.
Short Percent Of Float 0.17799999
Short Ratio 8.47
Source Interval 15
State CO
Symbol PALI
Target High Price 25.0
Target Low Price 5.0
Target Mean Price 9.8
Target Median Price 7.5
Total Cash 125,172,000
Total Cash Per Share 0.718
Total Debt 0
Total Revenue 500,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps 0.6
Trailing P E 2.6499999
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 1.90595
Two Hundred Day Average Change -0.31594992
Two Hundred Day Average Change Percent -0.1657703
Type Disp Equity
Volume 1,571,663
Website https://www.palisadebio.com
Zip 80,237