OnKure Therapeutics, Inc. (OKUR)Healthcare | Biotechnology | Boulder, United States | NasdaqGM
3.79 USD
-0.04
(-1.044%) ⇩
(Aug. 28, 2026, 4 p.m.
EDT)
After hours: 3.79 |
Hot Take ↕ | Aug. 22, 2026, 2:07 a.m. EDT
The investment case for OnKure Therapeutics is defined by a catastrophic multi-year price collapse that has erased over 96% of shareholder value since 2021. While the company boasts a pristine balance sheet with massive liquidity relative to debt and a 'strong buy' analyst consensus driven by a $150 million capital raise, the market has priced in a severe structural deterioration. The stock has suffered two consecutive years of negative returns, culminating in a staggering 81.5% drop last year, signaling that investors view the current business trajectory as unsustainable despite the cash on hand. The recent price action shows a fragile, range-bound recovery attempt, but without a proven path to profitability or a catalyst to reverse the multi-year decline, the risk of permanent capital loss remains high. The absence of a dividend and the deep discount to book value reflect the market's skepticism regarding the ability to generate free cash flow soon enough to justify the current valuation. |
| Model | MAE |
|---|---|
| AutoARIMA ✓ | 0.032146 |
| AutoETS | 0.032146 |
| AutoTheta | 0.032148 |
| MSTL | 0.036309 |
Forecast horizon: 45 days | Selected: AutoARIMA
| Forecast Reliability | |
|---|---|
| Score | 46% |
| H-stat | 2.98 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.930 |
| Excess Kurtosis | -0.26 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 0.538 |
| Market Cap | 153,098,864 |
| Forward P/E | -2.48 |
| Website | https://onkuretherapeutics.com |
As of Aug. 22, 2026, 2:07 a.m. EDT: Options activity is virtually dormant with negligible open interest and volume across all strikes. The sparse data suggests a lack of speculative positioning or hedging activity, indicating the market is effectively ignoring near-term directional bets.
| Attribute | Value |
|---|---|
| 52 Week Change | 0.38267148 |
| Address1 | 6,707 Winchester Circle |
| Address2 | Suite 400 |
| All Time High | 171.8 |
| All Time Low | 1.7 |
| Ask | 5.32 |
| Ask Size | 2 |
| Average Daily Volume10 Day | 159,820 |
| Average Daily Volume3 Month | 291,759 |
| Average Volume | 291,759 |
| Average Volume10Days | 159,820 |
| Bid | 3.02 |
| Bid Size | 2 |
| Book Value | 4.25 |
| City | Boulder |
| Compensation As Of Epoch Date | 1,767,139,200 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 3.79 |
| Current Ratio | 26.747 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,786,665,600 |
| Day High | 4.02 |
| Day Low | 3.675 |
| Debt To Equity | 0.538 |
| Display Name | OnKure Therapeutics |
| Earnings Timestamp End | 1,755,261,000 |
| Earnings Timestamp Start | 1,754,915,400 |
| Ebitda | -61,737,000 |
| Ebitda Margins | 0.0 |
| Enterprise To Ebitda | 0.356 |
| Enterprise Value | -21,978,988 |
| Eps Current Year | -1.83 |
| Eps Forward | -1.52667 |
| Eps Trailing Twelve Months | -2.98 |
| Esg Populated | 0 |
| Exchange | NGM |
| Exchange Data Delayed By | 0 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fifty Day Average | 4.1702 |
| Fifty Day Average Change | -0.3801999 |
| Fifty Day Average Change Percent | -0.09117067 |
| Fifty Two Week Change Percent | 38.267147 |
| Fifty Two Week High | 5.38 |
| Fifty Two Week High Change | -1.5900002 |
| Fifty Two Week High Change Percent | -0.29553905 |
| Fifty Two Week Low | 2.23 |
| Fifty Two Week Low Change | 1.56 |
| Fifty Two Week Low Change Percent | 0.6995515 |
| Fifty Two Week Range | 2.23 - 5.38 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,617,888,600,000 |
| Float Shares | 21,356,943 |
| Forward Eps | -1.52667 |
| Forward P E | -2.4825273 |
| Free Cashflow | -27,106,500 |
| Full Exchange Name | NasdaqGM |
| Full Time Employees | 45 |
| Fullday Change | -0.04 |
| Fullday Change Percent | -1.04439 |
| Fullday Price | 3.79 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Gross Margins | 0.0 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.104490004 |
| Held Percent Institutions | 0.87217003 |
| Implied Shares Outstanding | 40,395,480 |
| Industry | Biotechnology |
| Industry Disp | Biotechnology |
| Industry Key | biotechnology |
| Is Earnings Date Estimate | 1 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Last Split Date | 1,728,259,200 |
| Last Split Factor | 1:10 |
| Long Business Summary | OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases. Its lead product candidate includes OKI-219, a selective inhibitor of phosphoinositide 3-kinase alpha (PI3Ka) harboring the H1047R mutation that is in Phase 1 clinical trial for the treatment of solid tumors, including breast cancer. The company was founded in 2011 and is headquartered in Boulder, Colorado. |
| Long Name | OnKure Therapeutics, Inc. |
| Market | us_market |
| Market Cap | 153,098,864 |
| Market State | CLOSED |
| Max Age | 86,400 |
| Message Board Id | finmb_142375117 |
| Most Recent Quarter | 1,782,777,600 |
| Net Income To Common | -58,705,000 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 158,348,004 |
| Number Of Analyst Opinions | 4 |
| Open | 3.83 |
| Operating Cashflow | -47,841,000 |
| Operating Margins | 0.0 |
| Payout Ratio | 0.0 |
| Phone | 720-307-2892 |
| Post Market Change | 0.0 |
| Post Market Change Percent | 0.0 |
| Post Market Price | 3.79 |
| Post Market Time | 1,787,959,805 |
| Previous Close | 3.83 |
| Price Eps Current Year | -2.0710382 |
| Price Hint | 4 |
| Price To Book | 0.8917647 |
| Profit Margins | 0.0 |
| Quick Ratio | 26.552 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | none |
| Region | US |
| Regular Market Change | -0.04 |
| Regular Market Change Percent | -1.04439 |
| Regular Market Day High | 4.02 |
| Regular Market Day Low | 3.675 |
| Regular Market Day Range | 3.675 - 4.02 |
| Regular Market Open | 3.83 |
| Regular Market Previous Close | 3.83 |
| Regular Market Price | 3.79 |
| Regular Market Time | 1,787,947,200 |
| Regular Market Volume | 432,473 |
| Return On Assets | -0.29264998 |
| Return On Equity | -0.46912998 |
| Sand P52 Week Change | 0.20504117 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Shares Outstanding | 40,395,480 |
| Shares Percent Shares Out | 0.026500002 |
| Shares Short | 1,071,973 |
| Shares Short Previous Month Date | 1,784,073,600 |
| Shares Short Prior Month | 1,181,591 |
| Short Name | OnKure Therapeutics, Inc. |
| Short Percent Of Float | 0.0295 |
| Short Ratio | 8.8 |
| Source Interval | 15 |
| State | CO |
| Symbol | OKUR |
| Target High Price | 21.0 |
| Target Low Price | 11.0 |
| Target Mean Price | 15.5 |
| Target Median Price | 15.0 |
| Total Cash | 176,386,000 |
| Total Cash Per Share | 4.356 |
| Total Debt | 926,000 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -2.98 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 3.6493 |
| Two Hundred Day Average Change | 0.14069986 |
| Two Hundred Day Average Change Percent | 0.0385553 |
| Type Disp | Equity |
| Volume | 432,473 |
| Website | https://onkuretherapeutics.com |
| Zip | 80,301 |