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NuCana plc (NCNA)

Healthcare | Biotechnology | Edinburgh, United Kingdom | NasdaqCM
1.05 USD

Short-term:★☆☆☆☆Long-term:⯪☆☆☆☆Dividends:☆☆☆☆☆
Hot Take ↕ | Oct. 10, 2026, 8:39 a.m. EDT

The immediate outlook is severely clouded by a relentless multi-year price collapse, with seven consecutive years of negative annual returns ending in a massive 98.77% drop last year. This trajectory signals profound structural deterioration where the market has repeatedly rejected the business model, rendering any short-term technical bounce or minor FDA clearance news insufficient to generate a bullish entry. While the company boasts a pristine balance sheet with negligible debt and massive cash reserves relative to obligations, these assets cannot offset the reality that the core business is generating significant losses and destroying shareholder value. With no dividend history to provide income and a forward P/E indicating no earnings power, the investment case relies entirely on a speculative turnaround that the price action suggests investors currently doubt. The recent price action shows volatility near key support levels, but the overwhelming weight of the long-term decline and deteriorating fundamentals warrants a strong avoidance stance.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.062087
AutoETS0.065354
AutoARIMA0.261247
AutoTheta0.283988

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 43%
H-stat 0.25
Ljung-Box p 0.000
Jarque-Bera p 0.134
Excess Kurtosis 0.55
Attribute Value
Sector Healthcare
Debt to Equity Ratio 3.317
Market Cap 4,370,069
Forward P/E -0.11
Beta 2.31
Website https://www.nucana.com

Info Dump

Attribute Value
52 Week Change -0.80410445
Address1 3 Lochside Way
All Time High 160,000.0
All Time Low 0.948
Ask 1.38
Ask Size 2
Average Daily Volume10 Day 477,910
Average Daily Volume3 Month 119,918
Average Volume 119,918
Average Volume10Days 477,910
Beta 2.314
Bid 0.9288
Bid Size 2
Book Value 6.209551
City Edinburgh
Compensation As Of Epoch Date 1,767,139,200
Country United Kingdom
Crypto Tradeable 0
Currency USD
Current Price 1.05
Current Ratio 4.729
Custom Price Alert Confidence HIGH
Date Short Interest 1,790,726,400
Day High 1.065
Day Low 1.03
Debt To Equity 3.317
Display Name NuCana
Dividend Yield 0.0
Earnings Timestamp End 1,755,518,400
Earnings Timestamp Start 1,755,082,740
Ebitda -14,400,000
Ebitda Margins 0.0
Enterprise To Ebitda 0.993
Enterprise Value -14,306,072
Eps Forward -9.43
Eps Trailing Twelve Months 0.0
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 15
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 1.3544
Fifty Day Average Change -0.3044001
Fifty Day Average Change Percent -0.22474903
Fifty Two Week Change Percent -80.410446
Fifty Two Week High 6.1
Fifty Two Week High Change -5.05
Fifty Two Week High Change Percent -0.8278689
Fifty Two Week Low 0.948
Fifty Two Week Low Change 0.10199994
Fifty Two Week Low Change Percent 0.10759487
Fifty Two Week Range 0.948 - 6.1
Financial Currency GBP
First Trade Date Milliseconds 1,506,605,400,000
Float Shares 4,309,196
Forward Eps -9.43
Forward P E -0.11134676
Free Cashflow -6,370,000
Full Exchange Name NasdaqCM
Full Time Employees 10
Fullday Change -0.01999998
Fullday Change Percent -1.9047601
Fullday Price 1.05
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.0
Has Pre Post Market Data 1
Held Percent Insiders 0.000010000001
Held Percent Institutions 0.025969999
Implied Shares Outstanding 4,161,971
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,754,870,400
Last Split Factor 1:200
Long Business Summary NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of medicines to treat patients with cancer in the United States. It applies its ProTide technology to transform prescribed chemotherapy agents and nucleoside analogs into medicines. The company is developing medicines to overcome the limitations of nucleoside analogs and generate concentrations of anti-cancer metabolites in cancer cells. Its pipeline includes NUC-3373, a chemical entity derived from the nucleoside analog 5-fluorouracil that is in Phase 1b/2 study in patients with metastatic colorectal cancer; Phase 2 clinical trial for the second-line treatment of patients with advanced colorectal cancer; and Phase 1b/2 modular clinical trial for patients with advanced solid tumors and lung cancer. It also developing NUC-7738, a ProTide transformation of 3'-deoxyadenosine, which is in the Phase 2 part of a Phase 1/2 clinical trial for patients with advanced solid tumors. It has an assignment, license, and collaboration agreement with Cardiff ProTides Ltd to discover, drug design, and in vitro screen purine and pyrimidine-based nucleosides as potential drug candidates. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is based in Edinburgh, the United Kingdom.
Long Name NuCana plc
Market us_market
Market Cap 4,370,069
Market State POST
Max Age 86,400
Message Board Id finmb_50918463
Most Recent Quarter 1,782,777,600
Net Income To Common -9,711,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 5,452,181
Open 1.05
Operating Cashflow -5,117,000
Operating Margins 0.0
Payout Ratio 0.0
Phone 44 13 1357 1111
Previous Close 1.05
Price Hint 4
Price To Book 0.16909435
Profit Margins 0.0
Quick Ratio 4.557
Quote Source Name Delayed Quote
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change 0.0
Regular Market Change Percent 0.0
Regular Market Day High 1.065
Regular Market Day Low 1.03
Regular Market Day Range 1.03 - 1.065
Regular Market Open 1.05
Regular Market Previous Close 1.05
Regular Market Price 1.05
Regular Market Time 1,792,008,000
Regular Market Volume 38,043
Return On Assets -0.43487
Return On Equity -0.70258003
Sand P52 Week Change 0.17004645
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 4,161,971
Shares Percent Shares Out 0.024
Shares Short 99,936
Shares Short Previous Month Date 1,788,134,400
Shares Short Prior Month 158,689
Short Name NuCana plc
Short Percent Of Float 0.024
Short Ratio 0.53
Source Interval 15
Symbol NCNA
Total Cash 19,503,000
Total Cash Per Share 4.526
Total Debt 672,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps 0.0
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 1.91345
Two Hundred Day Average Change -0.86345005
Two Hundred Day Average Change Percent -0.451253
Type Disp Equity
Volume 38,043
Website https://www.nucana.com
Zip EH12 9DT