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Nautilus Biotechnology, Inc. (NAUT)

Healthcare | Biotechnology | Seattle, United States | NasdaqCM
1.78 USD -0.11 (-5.820%) ⇩ (July 13, 2026, 4 p.m. EDT)
After hours: 1.81 +0.03 (1.685%) ⇧ (July 13, 2026, 7:48 p.m. EDT)

Short-term:★☆☆☆☆Long-term:★☆☆☆☆Dividends:☆☆☆☆☆
Hot Take | July 11, 2026, 6:37 a.m. EDT

The investment case for Nautilus Biotechnology is currently broken by a catastrophic multi-year decline and deteriorating fundamentals. Over the last four years, the stock has lost over 92% of its value, with the most recent annual performance showing a massive drop of nearly 69%. While the company recently secured a customer for its Tau assay and insiders are buying, these positive developments are insufficient to counteract the market's verdict on the business's trajectory. The balance sheet shows significant losses and negative free cash flow, and the negative earnings per share indicate the company is not yet profitable. With no dividend to provide income and a price chart that has been in a relentless freefall, there is no margin of safety here. The options market confirms this pessimism, with traders loading up on long-dated puts to protect against further drops rather than buying calls for a rebound. Until the company demonstrates sustained profitability and a reversal in its multi-year price trend, this remains a speculative trap rather than a viable investment.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL ✓0.106410
AutoTheta0.111922
AutoETS0.111925
AutoARIMA0.139042

Forecast horizon: 45 days | Selected: MSTL

Forecast Reliability
Score 33%
H-stat 4.41
Ljung-Box p 0.000
Jarque-Bera p 0.207
Excess Kurtosis 0.09
Attribute Value
Sector Healthcare
Debt to Equity Ratio 19.993
Market Cap 226,200,368
Forward P/E -2.41
Beta 0.81
Previous Name ARYA Sciences Acquisition Corp III
Website https://www.nautilus.bio

As of July 11, 2026, 6:37 a.m. EDT: Speculators are overwhelmingly positioning for downside protection rather than upside speculation. Call volume and open interest are negligible across all expirations, while put open interest is concentrated significantly further out in time (December) compared to the near term. This distribution suggests a 'buy the dip' strategy where investors are hedging against further declines rather than betting on a recovery. The implied volatility for puts is notably higher than calls, reinforcing the fear of continued weakness.


Info Dump

Attribute Value
52 Week Change 1.3984771
Address1 2,701 Eastlake Avenue East
All Time High 25.886
All Time Low 0.62
Ask 2.3
Ask Size 2
Average Daily Volume10 Day 2,015,310
Average Daily Volume3 Month 650,522
Average Volume 650,522
Average Volume10Days 2,015,310
Beta 0.805
Bid 1.34
Bid Size 2
Book Value 1.136
City Seattle
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 1.78
Current Ratio 11.846
Custom Price Alert Confidence HIGH
Date Short Interest 1,782,777,600
Day High 1.9
Day Low 1.78
Debt To Equity 19.993
Display Name Nautilus Biotechnology
Earnings Call Timestamp End 1,785,268,800
Earnings Call Timestamp Start 1,785,268,800
Earnings Timestamp 1,785,241,800
Earnings Timestamp End 1,785,241,800
Earnings Timestamp Start 1,785,241,800
Ebitda -62,495,000
Ebitda Margins 0.0
Enterprise To Ebitda -2.547
Enterprise Value 159,204,368
Eps Forward -0.74
Eps Trailing Twelve Months -0.43
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 2.3913
Fifty Day Average Change -0.6113
Fifty Day Average Change Percent -0.25563502
Fifty Two Week Change Percent 139.8477
Fifty Two Week High 4.31
Fifty Two Week High Change -2.53
Fifty Two Week High Change Percent -0.587007
Fifty Two Week Low 0.62
Fifty Two Week Low Change 1.16
Fifty Two Week Low Change Percent 1.8709676
Fifty Two Week Range 0.62 - 4.31
Financial Currency USD
First Trade Date Milliseconds 1,596,807,000,000
Float Shares 55,809,221
Forward Eps -0.74
Forward P E -2.4054053
Free Cashflow -28,882,124
Full Exchange Name NasdaqCM
Full Time Employees 127
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.0
Has Pre Post Market Data 1
Held Percent Insiders 0.33206
Held Percent Institutions 0.40733
Implied Shares Outstanding 127,078,855
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Is Earnings Date Estimate 0
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Nautilus Biotechnology, Inc., a development stage life sciences company, engages in creating a platform technology for quantifying and unlocking the complexity of the proteome in the United States. The company develops Nautilus Voyager Platform, which includes an end-to-end solution comprising instruments, reagents, consumables, and software analysis. It also provides nautilus voyager instrument, a high-resolution optical imaging system with integrated fluidics and liquid handling sub-system to deposit protein libraries onto a flow cell and to process labeled multi-affinity reagent binding and imaging cycles rapidly to decode and quantify the proteins present in biological samples. In addition, the company offers single-molecule library preparation kits, flow cells, affinity reagents, and instrument run buffers to perform multi-cycle analysis runs. It has a research collaboration agreement Genentech, Buck Institute, Allen Institute, Cornell University and the Qatar Foundation, and Michael J. Fox Foundation. Nautilus Biotechnology, Inc. was founded in 2016 and is headquartered in Seattle, Washington.
Long Name Nautilus Biotechnology, Inc.
Market us_market
Market Cap 226,200,368
Market State PREPRE
Max Age 86,400
Message Board Id finmb_568970644
Most Recent Quarter 1,774,915,200
Name Change Date 2,026-07-13
Net Income To Common -57,085,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 240,179,035
Number Of Analyst Opinions 1
Open 1.86
Operating Cashflow -49,859,000
Operating Margins 0.0
Payout Ratio 0.0
Phone 206 333 2001
Post Market Change 0.029999971
Post Market Change Percent 1.6853917
Post Market Price 1.81
Post Market Time 1,783,986,480
Prev Name ARYA Sciences Acquisition Corp III
Previous Close 1.89
Price Hint 4
Price To Book 1.5669013
Profit Margins 0.0
Quick Ratio 11.491
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change -0.11
Regular Market Change Percent -5.82011
Regular Market Day High 1.9
Regular Market Day Low 1.78
Regular Market Day Range 1.78 - 1.9
Regular Market Open 1.86
Regular Market Previous Close 1.89
Regular Market Price 1.78
Regular Market Time 1,783,972,801
Regular Market Volume 845,104
Return On Assets -0.19766001
Return On Equity -0.33693
Sand P52 Week Change 0.20847368
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 127,078,855
Shares Percent Shares Out 0.0064999997
Shares Short 829,522
Shares Short Previous Month Date 1,780,012,800
Shares Short Prior Month 760,157
Short Name Nautilus Biotechnology, Inc.
Short Percent Of Float 0.013300001
Short Ratio 0.97
Source Interval 15
State WA
Symbol NAUT
Target High Price 4.0
Target Low Price 4.0
Target Mean Price 4.0
Target Median Price 4.0
Total Cash 95,869,000
Total Cash Per Share 0.754
Total Debt 28,873,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -0.43
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 2.178945
Two Hundred Day Average Change -0.3989451
Two Hundred Day Average Change Percent -0.18309094
Type Disp Equity
Volume 845,104
Website https://www.nautilus.bio
Zip 98,102