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Mineralys Therapeutics, Inc. (MLYS)

Healthcare | Biotechnology | Radnor, United States | NasdaqGS
25.60 USD -0.41 (-1.576%) ⇩ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 25.60

Short-term:★★☆☆☆Long-term:★★☆☆☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 5:03 a.m. EDT

Mineralys Therapeutics presents a classic biotech value trap with a fortress-like balance sheet masking severe operational distress. While the company holds substantial cash reserves relative to debt, it is burning through capital aggressively with negative free cash flow and no path to profitability visible in the near term. The lack of dividends and negative earnings confirm that this is a pure equity play reliant on future funding or a successful clinical milestone, neither of which is guaranteed. The short-term outlook remains bearish due to persistent insider selling, including executives liquidating positions after option exercises, which signals a lack of confidence in the immediate future. Although the statistical forecast model shows a slight upward lean, its low reliability makes it insufficient to counteract the fundamental risks. Long-term, the stock is neutral-to-negative because the market has already priced in the potential for a turnaround; the low valuation reflects the high probability of dilution or failure. The recent price recovery is likely a technical bounce off lows rather than a fundamental inflection. Investors should avoid this security until there is concrete evidence of revenue generation or a definitive catalyst that changes the burn rate dynamic.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoTheta ✓0.043832
MSTL0.056642
AutoETS0.069655
AutoARIMA0.069663

Forecast horizon: 45 days | Selected: AutoTheta

Forecast Reliability
Score 37%
H-stat 0.20
Ljung-Box p 0.000
Jarque-Bera p 0.322
Excess Kurtosis 0.56
Attribute Value
Sector Healthcare
Debt to Equity Ratio 17.719
Market Cap 2,256,857,088
Forward P/E -10.24
Beta 0.68
Website https://mineralystx.com

As of Aug. 22, 2026, 5:03 a.m. EDT: Speculators are positioning defensively with heavy out-of-the-money put volume relative to calls, particularly in the 2027-01-15 and 2028-01-21 expirations where OTM put open interest dominates. This suggests a fear of significant downside rather than a bullish bet on a rally. Call activity is sparse and concentrated at strikes far above the current price, indicating limited speculative upside conviction.


Info Dump

Attribute Value
52 Week Change -0.11295909
Address1 150 N. Radnor Chester Road
Address2 Suite F200
All Time High 47.65
All Time Low 5.85
Ask 25.63
Ask Size 1
Audit Risk 6
Average Daily Volume10 Day 806,390
Average Daily Volume3 Month 1,305,880
Average Volume 1,305,880
Average Volume10Days 806,390
Beta 0.681
Bid 18.52
Bid Size 2
Board Risk 10
Book Value 6.236
City Radnor
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 8
Country United States
Crypto Tradeable 0
Currency USD
Current Price 25.6
Current Ratio 34.464
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 25.91
Day Low 25.25
Debt To Equity 17.719
Display Name Mineralys Therapeutics
Earnings Call Timestamp End 1,786,480,200
Earnings Call Timestamp Start 1,786,480,200
Earnings Timestamp 1,786,478,400
Earnings Timestamp End 1,794,340,800
Earnings Timestamp Start 1,794,340,800
Ebitda -370,752,000
Ebitda Margins 0.0
Enterprise To Ebitda -4.584
Enterprise Value 1,699,421,312
Eps Current Year -4.42857
Eps Forward -2.5
Eps Trailing Twelve Months -4.14
Esg Populated 0
Exchange NMS
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 26.8153
Fifty Day Average Change -1.2152996
Fifty Day Average Change Percent -0.045321126
Fifty Two Week Change Percent -11.295909
Fifty Two Week High 47.65
Fifty Two Week High Change -22.050001
Fifty Two Week High Change Percent -0.4627492
Fifty Two Week Low 22.0
Fifty Two Week Low Change 3.6000004
Fifty Two Week Low Change Percent 0.16363639
Fifty Two Week Range 22.0 - 47.65
Financial Currency USD
First Trade Date Milliseconds 1,676,039,400,000
Float Shares 66,416,556
Forward Eps -2.5
Forward P E -10.24
Free Cashflow -203,456,368
Full Exchange Name NasdaqGS
Full Time Employees 76
Fullday Change -0.41
Fullday Change Percent -1.57632
Fullday Price 25.6
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,785,542,400
Gross Margins 0.0
Has Pre Post Market Data 1
Held Percent Insiders 0.00787
Held Percent Institutions 1.17779
Implied Shares Outstanding 88,158,479
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,023-02-10
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Mineralys Therapeutics, Inc., a biopharmaceutical company, develops medicines to target diseases driven by dysregulated aldosterone in the United States. It is developing lorundrostat, a proprietary, orally administered, highly selective aldosterone synthase inhibitor for the treatment of cardiorenal conditions affected by dysregulated aldosterone, such as hypertension, chronic kidney disease, and obstructive sleep apnea. The company was formerly known as Catalys SC1, Inc. and changed its name to Mineralys Therapeutics, Inc. in May 2020. Mineralys Therapeutics, Inc. was incorporated in 2019 and is headquartered in Radnor, Pennsylvania.
Long Name Mineralys Therapeutics, Inc.
Market us_market
Market Cap 2,256,857,088
Market State CLOSED
Max Age 86,400
Message Board Id finmb_710468587
Most Recent Quarter 1,782,777,600
Net Income To Common -349,576,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 2,299,463,078
Number Of Analyst Opinions 8
Open 25.81
Operating Cashflow -138,787,008
Operating Margins 0.0
Overall Risk 9
Payout Ratio 0.0
Phone 888 378 6240
Post Market Change 0.0
Post Market Change Percent 0.0
Post Market Price 25.6
Post Market Time 1,787,959,806
Previous Close 26.01
Price Eps Current Year -5.7806473
Price Hint 2
Price To Book 4.1051955
Profit Margins 0.0
Quick Ratio 34.236
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change -0.41
Regular Market Change Percent -1.57632
Regular Market Day High 25.91
Regular Market Day Low 25.25
Regular Market Day Range 25.25 - 25.91
Regular Market Open 25.81
Regular Market Previous Close 26.01
Regular Market Price 25.6
Regular Market Time 1,787,947,201
Regular Market Volume 812,833
Return On Assets -0.46183997
Return On Equity -0.80877
Sand P52 Week Change 0.20204377
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 8
Shares Outstanding 88,158,479
Shares Percent Shares Out 0.1091
Shares Short 9,645,951
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 9,552,513
Short Name Mineralys Therapeutics, Inc.
Short Percent Of Float 0.1306
Short Ratio 14.38
Source Interval 15
State PA
Symbol MLYS
Target High Price 56.0
Target Low Price 30.0
Target Mean Price 48.5
Target Median Price 52.0
Total Cash 661,411,968
Total Cash Per Share 7.481
Total Debt 97,617,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -4.14
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 30.0427
Two Hundred Day Average Change -4.4426994
Two Hundred Day Average Change Percent -0.1478795
Type Disp Equity
Volume 812,833
Website https://mineralystx.com
Zip 19,087