Madrigal Pharmaceuticals, Inc. (MDGL)Healthcare | Biotechnology | West Conshohocken, United States | NasdaqGS
459.81 USD
-0.20
(-0.043%) ⇩
(Oct. 15, 2026, 4 p.m.
EDT)
After hours: 461.69 +1.88 (0.409%) ⇧ (Oct. 15, 2026, 4:47 p.m. EDT) |
Hot Take ↕ | Oct. 10, 2026, 7:12 a.m. EDT
Madrigal Pharmaceuticals offers a compelling long-term growth story driven by 71% revenue expansion and industry-leading gross margins, backed by a resilient balance sheet. However, the absence of profitability and negative free cash flow prevent it from being a top-tier buy, capping the long-term rating at a solid but cautious level. In the short term, technicals are weak with the stock trading below key moving averages following a sharp 9% decline over the past fortnight, creating a near-term headwind despite strong analyst consensus. Options activity reveals a mixed sentiment with significant call positioning above current prices suggesting a potential rebound, balanced by deep out-of-the-money speculation and hedging activity at lower levels. |
| Model | MAE |
|---|---|
| AutoARIMA ✓ | 0.033767 |
| MSTL | 0.034686 |
| AutoETS | 0.034764 |
| AutoTheta | 0.074140 |
Forecast horizon: 45 days | Selected: AutoARIMA
| Forecast Reliability | |
|---|---|
| Score | 40% |
| H-stat | 0.32 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.005 |
| Excess Kurtosis | 1.34 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 66.4 |
| Revenue per Share | 56.147 |
| Market Cap | 10,623,508,480 |
| Forward P/E | 47.77 |
| Beta | -1.05 |
| Profit Margins | -25.32% |
| Website | https://www.madrigalpharma.com |
As of Oct. 10, 2026, 7:12 a.m. EDT: Speculators are positioning for volatility with elevated implied volatility across expirations. Call open interest clusters above the current price at 520, 560, and 600 strikes, suggesting a bullish bias for a recovery, while put activity at lower strikes indicates hedging against further downside. Deep out-of-the-money calls show inflated premiums, hinting at lottery-ticket speculation.
| Attribute | Value |
|---|---|
| 52 Week Change | 0.04044056 |
| Address1 | 1,001 Conshohocken State Road |
| Address2 | Suite 2-350 |
| All Time High | 615.0 |
| All Time Low | 5.25 |
| Ask | 468.59 |
| Ask Size | 2 |
| Audit Risk | 2 |
| Average Analyst Rating | 1.3 - Strong Buy |
| Average Daily Volume10 Day | 312,630 |
| Average Daily Volume3 Month | 294,510 |
| Average Volume | 294,510 |
| Average Volume10Days | 312,630 |
| Beta | -1.052 |
| Bid | 494.58 |
| Bid Size | 1 |
| Board Risk | 3 |
| Book Value | 22.678 |
| City | West Conshohocken |
| Compensation As Of Epoch Date | 1,767,139,200 |
| Compensation Risk | 5 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 459.81 |
| Current Ratio | 3.205 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,790,726,400 |
| Day High | 468.7218 |
| Day Low | 456.22 |
| Debt To Equity | 66.4 |
| Display Name | Madrigal Pharmaceuticals |
| Dividend Date | 1,469,404,800 |
| Dividend Yield | 0.0 |
| Earnings Call Timestamp End | 1,785,412,800 |
| Earnings Call Timestamp Start | 1,785,412,800 |
| Earnings Timestamp | 1,785,414,600 |
| Earnings Timestamp End | 1,793,795,400 |
| Earnings Timestamp Start | 1,793,795,400 |
| Ebitda | -321,097,984 |
| Ebitda Margins | -0.25009 |
| Enterprise To Ebitda | -31.556 |
| Enterprise To Revenue | 7.892 |
| Enterprise Value | 10,132,506,624 |
| Eps Current Year | -6.4925 |
| Eps Forward | 9.625 |
| Eps Trailing Twelve Months | -13.06 |
| Esg Populated | 0 |
| Exchange | NMS |
| Exchange Data Delayed By | 15 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fifty Day Average | 516.7388 |
| Fifty Day Average Change | -56.928772 |
| Fifty Day Average Change Percent | -0.11016934 |
| Fifty Two Week Change Percent | 4.044056 |
| Fifty Two Week High | 615.0 |
| Fifty Two Week High Change | -155.19 |
| Fifty Two Week High Change Percent | -0.25234148 |
| Fifty Two Week Low | 393.61 |
| Fifty Two Week Low Change | 66.20001 |
| Fifty Two Week Low Change Percent | 0.16818683 |
| Fifty Two Week Range | 393.61 - 615.0 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,170,772,200,000 |
| Float Shares | 13,723,389 |
| Forward Eps | 9.625 |
| Forward P E | 47.77247 |
| Free Cashflow | -80,466,248 |
| Full Exchange Name | NasdaqGS |
| Full Time Employees | 915 |
| Fullday Change | 1.6799927 |
| Fullday Change Percent | 0.36520785 |
| Fullday Price | 459.81 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Governance Epoch Date | 1,790,812,800 |
| Gross Margins | 0.91476995 |
| Gross Profits | 1,174,515,968 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.05827 |
| Held Percent Institutions | 1.04733 |
| Implied Shares Outstanding | 23,104,126 |
| Industry | Biotechnology |
| Industry Disp | Biotechnology |
| Industry Key | biotechnology |
| Ir Website | http://ir.syntapharma.com/phoenix.zhtml?c=147988&p=irol-irhome |
| Is Earnings Date Estimate | 0 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Last Split Date | 1,469,404,800 |
| Last Split Factor | 1:35 |
| Long Business Summary | Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania. |
| Long Name | Madrigal Pharmaceuticals, Inc. |
| Market | us_market |
| Market Cap | 10,623,508,480 |
| Market State | POSTPOST |
| Max Age | 86,400 |
| Message Board Id | finmb_144939852 |
| Most Recent Quarter | 1,782,777,600 |
| Net Income To Common | -325,095,008 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 11,850,106,225 |
| Number Of Analyst Opinions | 18 |
| Open | 464.78 |
| Operating Cashflow | -197,716,000 |
| Operating Margins | -0.15459 |
| Overall Risk | 5 |
| Payout Ratio | 0.0 |
| Phone | 267 824 2827 |
| Post Market Change | 1.8800049 |
| Post Market Change Percent | 0.4088656 |
| Post Market Price | 461.69 |
| Post Market Time | 1,792,097,240 |
| Previous Close | 460.01 |
| Price Eps Current Year | -70.82172 |
| Price Hint | 2 |
| Price To Book | 20.275599 |
| Price To Sales Trailing12 Months | 8.274147 |
| Profit Margins | -0.2532 |
| Quick Ratio | 2.755 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | strong_buy |
| Recommendation Mean | 1.26316 |
| Region | US |
| Regular Market Change | -0.200012 |
| Regular Market Change Percent | -0.04348 |
| Regular Market Day High | 468.7218 |
| Regular Market Day Low | 456.22 |
| Regular Market Day Range | 456.22 - 468.7218 |
| Regular Market Open | 464.78 |
| Regular Market Previous Close | 460.01 |
| Regular Market Price | 459.81 |
| Regular Market Time | 1,792,094,401 |
| Regular Market Volume | 266,074 |
| Return On Assets | -0.17844 |
| Return On Equity | -0.53306997 |
| Revenue Growth | 0.712 |
| Revenue Per Share | 56.147 |
| Sand P52 Week Change | 0.16440773 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Share Holder Rights Risk | 8 |
| Shares Outstanding | 23,104,126 |
| Shares Percent Shares Out | 0.1037 |
| Shares Short | 2,396,369 |
| Shares Short Previous Month Date | 1,788,134,400 |
| Shares Short Prior Month | 2,240,575 |
| Short Name | Madrigal Pharmaceuticals, Inc. |
| Short Percent Of Float | 0.12189999 |
| Short Ratio | 10.83 |
| Source Interval | 15 |
| State | PA |
| Symbol | MDGL |
| Target High Price | 962.0 |
| Target Low Price | 543.0 |
| Target Mean Price | 685.7778 |
| Target Median Price | 661.5 |
| Total Cash | 838,753,024 |
| Total Cash Per Share | 36.303 |
| Total Debt | 347,751,008 |
| Total Revenue | 1,283,939,968 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -13.06 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 506.42804 |
| Two Hundred Day Average Change | -46.618042 |
| Two Hundred Day Average Change Percent | -0.092052646 |
| Type Disp | Equity |
| Volume | 266,074 |
| Website | https://www.madrigalpharma.com |
| Zip | 19,428 |