Madrigal Pharmaceuticals, Inc. (MDGL)Healthcare | Biotechnology | West Conshohocken, United States | NasdaqGS
532.02 USD
+7.26
(1.383%)
⇧
(April 17, 2026, 4 p.m.
EDT)
After hours: 532.01 -0.01 (-0.010%) ⇩ (April 17, 2026, 5:46 p.m. EDT) Short-term: ★★★☆☆ | Long-term: ★★★★☆ | Dividends: ☆☆☆☆☆ |
Hot Take | April 19, 2026, 12:51 a.m. EDT
Madrigal presents a compelling asymmetric trade for long-horizon investors (4 stars) due to its strong cash position and quality pipeline, but it remains a volatile, zero-yield biotech play. The short-term outlook (3 stars) is neutral-to-mildly bullish, hampered by the lack of dividends and negative earnings, though options flow suggests speculators view the 600+ level as a likely resistance target rather than a hard ceiling. |
| Model | MAE |
|---|---|
| AutoETS ✓ | 0.078996 |
| AutoTheta | 0.079121 |
| AutoARIMA | 0.079237 |
| MSTL | 0.081502 |
Forecast horizon: 45 days | Selected: AutoETS
| Forecast Reliability | |
|---|---|
| Score | 80% |
| H-stat | 0.74 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.127 |
| Excess Kurtosis | -1.43 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 57.68 |
| Revenue per Share | 42.72 |
| Market Cap | 12,204,522,496 |
| Forward P/E | 41.58 |
| Beta | -1.01 |
| Profit Margins | -30.08% |
| Website | https://www.madrigalpharma.com |
As of April 19, 2026, 12:51 a.m. EDT: Speculator positioning shows a slight bullish bias despite the stock trading near recent highs. Call orders exceed put orders in short-term expirations (OTM OI % is 0.42 vs 0.99 for puts, a significant disparity). There is a distinct accumulation of Call OI at the 400-440 and 600-760 strikes, indicating a bullish target zone. Conversely, Put-heavy positioning is concentrated at deep OTM strikes (220-450) for near-term expirations, suggesting a 'buy call and maybe sell cheap insurance' strategy. Implied Volatility is elevated and fairly priced, with max pain for April likely situated below the current price, which could create a short-term headwind without a catalyst.
| Attribute | Value |
|---|---|
| 52 Week Change | 0.8033353 |
| Address1 | Four Tower Bridge |
| Address2 | 200 Barr Harbor Drive Suite 200 |
| All Time High | 615.0 |
| All Time Low | 5.25 |
| Ask | 533.12 |
| Ask Size | 2 |
| Audit Risk | 6 |
| Average Analyst Rating | 1.4 - Strong Buy |
| Average Daily Volume10 Day | 298,740 |
| Average Daily Volume3 Month | 365,552 |
| Average Volume | 365,552 |
| Average Volume10Days | 298,740 |
| Beta | -1.008 |
| Bid | 516.56 |
| Bid Size | 1 |
| Board Risk | 6 |
| Book Value | 26.385 |
| City | West Conshohocken |
| Compensation As Of Epoch Date | 1,735,603,200 |
| Compensation Risk | 5 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 532.02 |
| Current Ratio | 4.015 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,774,915,200 |
| Day High | 536.86 |
| Day Low | 522.81 |
| Debt To Equity | 57.68 |
| Display Name | Madrigal Pharmaceuticals |
| Dividend Date | 1,469,404,800 |
| Earnings Call Timestamp End | 1,771,506,000 |
| Earnings Call Timestamp Start | 1,771,506,000 |
| Earnings Timestamp | 1,771,507,800 |
| Earnings Timestamp End | 1,777,552,200 |
| Earnings Timestamp Start | 1,777,552,200 |
| Ebitda | -298,591,008 |
| Ebitda Margins | -0.31155002 |
| Enterprise To Ebitda | -38.744 |
| Enterprise To Revenue | 12.071 |
| Enterprise Value | 11,568,592,896 |
| Eps Current Year | -5.782 |
| Eps Forward | 12.794 |
| Eps Trailing Twelve Months | -12.87 |
| Esg Populated | 0 |
| Exchange | NMS |
| Exchange Data Delayed By | 0 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fifty Day Average | 473.2994 |
| Fifty Day Average Change | 58.72061 |
| Fifty Day Average Change Percent | 0.124066524 |
| Fifty Two Week Change Percent | 80.333534 |
| Fifty Two Week High | 615.0 |
| Fifty Two Week High Change | -82.97998 |
| Fifty Two Week High Change Percent | -0.1349268 |
| Fifty Two Week Low | 265.0 |
| Fifty Two Week Low Change | 267.02002 |
| Fifty Two Week Low Change Percent | 1.0076227 |
| Fifty Two Week Range | 265.0 - 615.0 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,170,772,200,000 |
| Float Shares | 12,490,813 |
| Forward Eps | 12.794 |
| Forward P E | 41.583557 |
| Free Cashflow | -115,079,752 |
| Full Exchange Name | NasdaqGS |
| Full Time Employees | 915 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Governance Epoch Date | 1,775,001,600 |
| Gross Margins | 0.94141996 |
| Gross Profits | 902,254,976 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.07711 |
| Held Percent Institutions | 1.04633 |
| Implied Shares Outstanding | 22,939,969 |
| Industry | Biotechnology |
| Industry Disp | Biotechnology |
| Industry Key | biotechnology |
| Ir Website | http://ir.syntapharma.com/phoenix.zhtml?c=147988&p=irol-irhome |
| Is Earnings Date Estimate | 1 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Last Split Date | 1,469,404,800 |
| Last Split Factor | 1:35 |
| Long Business Summary | Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania. |
| Long Name | Madrigal Pharmaceuticals, Inc. |
| Market | us_market |
| Market Cap | 12,204,522,496 |
| Market State | PREPRE |
| Max Age | 86,400 |
| Message Board Id | finmb_144939852 |
| Most Recent Quarter | 1,767,139,200 |
| Net Income To Common | -288,284,000 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 12,204,522,307 |
| Number Of Analyst Opinions | 14 |
| Open | 529.89 |
| Operating Cashflow | -189,552,992 |
| Operating Margins | -0.18565 |
| Overall Risk | 6 |
| Payout Ratio | 0.0 |
| Phone | 267 824 2827 |
| Post Market Change | -0.010009766 |
| Post Market Change Percent | -0.001881464 |
| Post Market Price | 532.01 |
| Post Market Time | 1,776,462,379 |
| Previous Close | 524.76 |
| Price Eps Current Year | -92.013145 |
| Price Hint | 2 |
| Price To Book | 20.16373 |
| Price To Sales Trailing12 Months | 12.734228 |
| Profit Margins | -0.3008 |
| Quick Ratio | 3.603 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | strong_buy |
| Recommendation Mean | 1.4375 |
| Region | US |
| Regular Market Change | 7.26001 |
| Regular Market Change Percent | 1.38349 |
| Regular Market Day High | 536.86 |
| Regular Market Day Low | 522.81 |
| Regular Market Day Range | 522.81 - 536.86 |
| Regular Market Open | 529.89 |
| Regular Market Previous Close | 524.76 |
| Regular Market Price | 532.02 |
| Regular Market Time | 1,776,456,001 |
| Regular Market Volume | 341,067 |
| Return On Assets | -0.16297 |
| Return On Equity | -0.42486 |
| Revenue Growth | 2.108 |
| Revenue Per Share | 42.72 |
| Sand P52 Week Change | 0.38150132 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Share Holder Rights Risk | 8 |
| Shares Outstanding | 22,939,969 |
| Shares Percent Shares Out | 0.17040001 |
| Shares Short | 3,909,299 |
| Shares Short Previous Month Date | 1,772,150,400 |
| Shares Short Prior Month | 3,742,574 |
| Short Name | Madrigal Pharmaceuticals, Inc. |
| Short Percent Of Float | 0.1965 |
| Short Ratio | 10.69 |
| Source Interval | 15 |
| State | PA |
| Symbol | MDGL |
| Target High Price | 964.0 |
| Target Low Price | 529.0 |
| Target Mean Price | 672.7857 |
| Target Median Price | 647.0 |
| Total Cash | 983,558,976 |
| Total Cash Per Share | 42.875 |
| Total Debt | 347,630,016 |
| Total Revenue | 958,403,008 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -12.87 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 458.60345 |
| Two Hundred Day Average Change | 73.416565 |
| Two Hundred Day Average Change Percent | 0.16008724 |
| Type Disp | Equity |
| Volume | 341,067 |
| Website | https://www.madrigalpharma.com |
| Zip | 19,428 |