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Generate Biomedicines, Inc. (GENB)

Healthcare | Biotechnology | Somerville, United States | NasdaqGS
12.26 USD -1.59 (-11.452%) ⇩ (Oct. 13, 2026, 4 p.m. EDT)

Short-term:★★☆☆☆Long-term:★☆☆☆☆Dividends:☆☆☆☆☆
Hot Take ↕ | Oct. 10, 2026, 4:36 a.m. EDT

The investment case for Generate Biomedicines is currently fractured between aggressive speculation on a potential turnaround and deep skepticism regarding its financial reality. On the fundamental side, the picture is stark: the company is burning cash with negative operating margins, shrinking revenue by nearly 38%, and trading at a forward P/E that implies negative earnings. The balance sheet, while liquid, cannot mask the structural deterioration of the business model. The price action confirms this distress, with the stock trading well below its 52-week high and failing to hold key moving averages, signaling a loss of institutional confidence. Despite these red flags, the options market tells a story of conflicting narratives. Traders are buying deep out-of-the-money calls at the $20 level, likely betting on a specific catalyst or a 'Nvidia-backed' narrative reframing the stock as a scaled AI developer. Yet, this optimism is hedged by significant put buying at lower strikes for longer-dated expirations, suggesting smart money is protecting against a failure to deliver. The statistical forecasting models are useless here due to extreme noise, which is typical for small-cap bioteics in distress. Ultimately, while the analyst consensus is a 'strong buy' based on potential, the actual data shows a company in a value trap where the market has already priced out the worst-case scenarios, leaving very little margin of safety for the average investor.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoTheta ✓0.100633
MSTL0.116082
AutoETS0.118782
AutoARIMA0.142394

Forecast horizon: 45 days | Selected: AutoTheta

Forecast Reliability
Score 28%
H-stat 1.89
Ljung-Box p 0.000
Jarque-Bera p 0.000
Excess Kurtosis 2.48
Attribute Value
Sector Healthcare
Debt to Equity Ratio 13.733
Revenue per Share 0.323
Market Cap 1,572,959,104
Forward P/E -5.38
Website https://generatebiomedicines.com

As of Oct. 10, 2026, 4:36 a.m. EDT: Speculators are positioning asymmetrically for downside protection rather than upside participation. In the near term (Nov 2026), there is heavy open interest in out-of-the-money calls at the $20 strike, suggesting a speculative bet on a significant rally to that level. However, this is outweighed by substantial in-the-money put volume and open interest in the April 2027 expiration at the $12.50 strike, indicating a hedge against a prolonged decline below current levels. Implied volatility is elevated across the board, reflecting uncertainty about the company's ability to execute its pipeline amidst revenue contraction.


Info Dump

Attribute Value
52 Week Change 0.09407115
Address1 101 South Street
Address2 Suite 900
All Time High 22.67
All Time Low 11.0
Ask 15.74
Ask Size 2
Average Analyst Rating 1.3 - Strong Buy
Average Daily Volume10 Day 993,260
Average Daily Volume3 Month 1,058,663
Average Volume 1,058,663
Average Volume10Days 993,260
Bid 9.9
Bid Size 2
Book Value 3.555
City Somerville
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 12.255
Current Ratio 8.303
Custom Price Alert Confidence HIGH
Date Short Interest 1,790,726,400
Day High 13.75
Day Low 12.25
Debt To Equity 13.733
Display Name Generate Biomedicines
Dividend Yield 0.0
Earnings Timestamp 1,786,019,400
Earnings Timestamp End 1,793,881,800
Earnings Timestamp Start 1,793,881,800
Ebitda -249,548,000
Ebitda Margins 0.0
Enterprise To Ebitda -4.721
Enterprise To Revenue 44.488
Enterprise Value 1,178,172,160
Eps Current Year -2.3
Eps Forward -2.28
Eps Trailing Twelve Months -2.53
Esg Populated 0
Exchange NMS
Exchange Data Delayed By 15
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 15.5162
Fifty Day Average Change -3.2612
Fifty Day Average Change Percent -0.21018033
Fifty Two Week Change Percent 9.407115
Fifty Two Week High 22.67
Fifty Two Week High Change -10.415
Fifty Two Week High Change Percent -0.45941773
Fifty Two Week Low 11.0
Fifty Two Week Low Change 1.2550001
Fifty Two Week Low Change Percent 0.11409092
Fifty Two Week Range 11.0 - 22.67
Financial Currency USD
First Trade Date Milliseconds 1,772,202,600,000
Float Shares 60,448,863
Forward Eps -2.28
Forward P E -5.375
Full Exchange Name NasdaqGS
Full Time Employees 312
Fullday Change 0.45499992
Fullday Change Percent 3.7127697
Fullday Price 12.71
Gmt Off Set Milliseconds -14,400,000
Gross Margins 0.0
Gross Profits -213,796,992
Has Pre Post Market Data 1
Held Percent Insiders 0.14049
Held Percent Institutions 0.77625
Implied Shares Outstanding 128,352,436
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,026-02-27
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Generate Biomedicines, Inc., engaged in the field of generative biology by using machine learning for drug discovery and development through the programming of novel protein therapeutics in the United States. It uses protein-based modalities for drug development. Its product includes GB-0895, is an investigational long-acting anti-TSLP monoclonal antibody in development for severe asthma that is intended to be dosed every six months; GB-4362, an MMAE payload neutralizer monoclonal antibody; GB-5267, A MUC16 CAR-T Cell therapy. In additional, it develops Generate Platform, designed to be a therapeutic area and protein modality agnostic system integrating computational innovation with scalable biohardware to address therapeutic challenges beyond the reach of traditional technologies. Generate Biomedicines, Inc. was formerly known as Generate Biologics, Inc. and changed its name to Generate Biomedicines, Inc. in February 2020. The company was incorporated in 2018 and is based in Somerville, Massachusetts.
Long Name Generate Biomedicines, Inc.
Market us_market
Market Cap 1,572,959,104
Market State PRE
Max Age 86,400
Message Board Id finmb_659065371
Most Recent Quarter 1,782,777,600
Net Income To Common -268,673,984
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 2,120,382,242
Number Of Analyst Opinions 5
Open 13.75
Operating Cashflow -237,022,000
Operating Margins -11.342099
Phone (888) 469-0055
Pre Market Change 0.45499992
Pre Market Change Percent 3.7127697
Pre Market Price 12.71
Pre Market Time 1,791,964,864
Previous Close 13.84
Price Eps Current Year -5.328261
Price Hint 2
Price To Book 3.4472573
Price To Sales Trailing12 Months 59.39505
Profit Margins 0.0
Quick Ratio 8.076
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.33333
Region US
Regular Market Change -1.585
Regular Market Change Percent -11.4523
Regular Market Day High 13.75
Regular Market Day Low 12.25
Regular Market Day Range 12.25 - 13.75
Regular Market Open 13.75
Regular Market Previous Close 13.84
Regular Market Price 12.255
Regular Market Time 1,791,921,601
Regular Market Volume 925,176
Revenue Growth -0.377
Revenue Per Share 0.323
Sand P52 Week Change 0.17502642
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 128,352,436
Shares Percent Shares Out 0.057800002
Shares Short 7,417,094
Shares Short Previous Month Date 1,788,134,400
Shares Short Prior Month 7,456,033
Short Name Generate Biomedicines, Inc.
Short Percent Of Float 0.0992
Short Ratio 6.27
Source Interval 15
State MA
Symbol GENB
Target High Price 30.0
Target Low Price 22.0
Target Mean Price 27.0
Target Median Price 27.0
Total Cash 457,415,008
Total Cash Per Share 3.564
Total Debt 62,628,000
Total Revenue 26,483,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -2.53
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 14.146815
Two Hundred Day Average Change -1.8918152
Two Hundred Day Average Change Percent -0.13372728
Type Disp Equity
Volume 925,176
Website https://generatebiomedicines.com
Zip 2,143