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Ensysce Biosciences, Inc. (ENSC)

Healthcare | Biotechnology | La Jolla, United States | NasdaqCM
0.28 USD +0.01 (2.075%) ⇧ (July 13, 2026, 4 p.m. EDT)

Short-term:★☆☆☆☆Long-term:⯪☆☆☆☆Dividends:☆☆☆☆☆
Hot Take | July 11, 2026, 4:32 a.m. EDT

The immediate outlook is severely compromised by a massive divergence between the market's pricing and the company's operational reality. While the recent price action shows a minor, fragile recovery from the lows, the underlying business is in freefall. The stock has endured four consecutive years of negative annual returns, culminating in a catastrophic 99.99% decline over the last seven years. This is not a temporary correction; it is a structural implosion where the market has completely reassessed the company's viability. Fundamentally, the enterprise is bleeding cash with negative operating cash flow, gross margins in the negative territory, and a shrinking revenue base. The balance sheet is fragile, with book value eroded to negative levels and a current ratio below 1.0, signaling liquidity stress. Although the price-to-sales metric appears deceptively low, it reflects a business that has lost nearly all of its value rather than a bargain opportunity. With no dividend to provide income and a statistical forecast leaning further down, the investment case is nonexistent.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
MSTL_70_105 ✓0.085044
MSTL_1050.096646
MSTL_700.123362
MSTL0.183751
AutoARIMA0.198287
AutoETS0.199029
AutoTheta0.240121

Forecast horizon: 60 days | Selected: MSTL_70_105

Forecast Reliability
Score 35%
H-stat 1.12
Ljung-Box p 0.000
Jarque-Bera p 0.208
Excess Kurtosis -0.88
Attribute Value
Sector Healthcare
Revenue per Share 1.202
Market Cap 4,233,203
Forward P/E -0.12
Beta 0.79
Profit Margins -250.36%
Previous Name Leisure Acquisition Corp.
Website https://www.ensysce.com

Info Dump

Attribute Value
52 Week Change -0.8772727
Address1 7,946 Ivanhoe Avenue
Address2 Suite 201
All Time High 86,364.0
All Time Low 0.23
Ask 0.3499
Ask Size 2
Average Daily Volume10 Day 604,310
Average Daily Volume3 Month 2,271,534
Average Volume 2,271,534
Average Volume10Days 604,310
Beta 0.793
Bid 0.1928
Bid Size 2
Book Value -0.037
City La Jolla
Compensation As Of Epoch Date 1,767,139,200
Country United States
Crypto Tradeable 0
Currency USD
Current Price 0.2755
Current Ratio 0.708
Custom Price Alert Confidence HIGH
Date Short Interest 1,782,777,600
Day High 0.2788
Day Low 0.2673
Display Name Ensysce Biosciences
Earnings Call Timestamp End 1,711,033,200
Earnings Call Timestamp Start 1,711,033,200
Earnings Timestamp End 1,755,201,600
Earnings Timestamp Start 1,755,201,600
Ebitda Margins 0.0
Enterprise To Revenue 0.684
Enterprise Value 3,219,729
Eps Forward -2.23
Eps Trailing Twelve Months -3.15
Esg Populated 0
Exchange NCM
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 0.301
Fifty Day Average Change -0.0255
Fifty Day Average Change Percent -0.08471761
Fifty Two Week Change Percent -87.72727
Fifty Two Week High 2.75
Fifty Two Week High Change -2.4745
Fifty Two Week High Change Percent -0.8998182
Fifty Two Week Low 0.23
Fifty Two Week Low Change 0.045499995
Fifty Two Week Low Change Percent 0.19782606
Fifty Two Week Range 0.23 - 2.75
Financial Currency USD
First Trade Date Milliseconds 1,521,034,200,000
Float Shares 14,684,206
Forward Eps -2.23
Forward P E -0.1235426
Free Cashflow -5,554,856
Full Exchange Name NasdaqCM
Full Time Employees 8
Gmt Off Set Milliseconds -14,400,000
Gross Margins -1.51456
Gross Profits -7,130,371
Has Pre Post Market Data 1
Held Percent Insiders 0.00061
Held Percent Institutions 0.03314
Implied Shares Outstanding 15,365,530
Industry Biotechnology
Industry Disp Biotechnology
Industry Key biotechnology
Ipo Expected Date 2,021-07-02
Is Earnings Date Estimate 1
Language en-US
Last Fiscal Year End 1,767,139,200
Last Split Date 1,733,443,200
Last Split Factor 1:15
Long Business Summary Ensysce Biosciences, Inc., a clinical-stage pharmaceutical company, develops prescription drugs for severe pain relief in opioid misuse, abuse, and overdose in the United States. It develops products using Trypsin Activated Abuse Protection (TAAP) platform, designed to release clinically effective drugs only when exposed to specific physiological conditions; and Multi-Pill Abuse Resistance (MPAR) platform, an over-dose protection opioid prodrug technology. The company's lead product candidate is PF614, a TAAP oxycodone prodrug candidate for the treatment of severe or chronic pain; and PF614-MPAR, a combination product of PF614 and nafamostat for overdose protection. It is also developing PF8001 and PF8026 are extended and immediate-release prodrugs of amphetamine for attention deficit hyperactivity disorder; and PF9001 to treat opioid use disorder. Ensysce Biosciences, Inc. was founded in 2003 and is based in La Jolla, California.
Long Name Ensysce Biosciences, Inc.
Market us_market
Market Cap 4,233,203
Market State PRE
Max Age 86,400
Message Board Id finmb_51791423
Most Recent Quarter 1,774,915,200
Name Change Date 2,026-07-13
Net Income To Common -11,786,542
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 4,191,716
Number Of Analyst Opinions 1
Open 0.2673
Operating Cashflow -9,599,805
Operating Margins -3.7068
Payout Ratio 0.0
Phone 858 263 4196
Pre Market Change -0.0058999956
Pre Market Change Percent -2.1415591
Pre Market Price 0.2696
Pre Market Time 1,784,017,639
Prev Name Leisure Acquisition Corp.
Previous Close 0.2699
Price Hint 4
Price To Book -7.4459457
Price To Sales Trailing12 Months 0.8991745
Profit Margins -2.50358
Quick Ratio 0.263
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key none
Region US
Regular Market Change 0.00560001
Regular Market Change Percent 2.07484
Regular Market Day High 0.2788
Regular Market Day Low 0.2673
Regular Market Day Range 0.2673 - 0.2788
Regular Market Open 0.2673
Regular Market Previous Close 0.2699
Regular Market Price 0.2755
Regular Market Time 1,783,972,801
Regular Market Volume 206,323
Return On Assets -2.1822
Return On Equity -11.4911
Revenue Growth -0.272
Revenue Per Share 1.202
Sand P52 Week Change 0.20847368
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Shares Outstanding 15,365,530
Shares Percent Shares Out 0.0119
Shares Short 182,353
Shares Short Previous Month Date 1,780,012,800
Shares Short Prior Month 50,601
Short Name Ensysce Biosciences, Inc.
Short Percent Of Float 0.0119
Short Ratio 0.15
Source Interval 15
State CA
Symbol ENSC
Target High Price 16.45
Target Low Price 16.45
Target Mean Price 16.45
Target Median Price 16.45
Total Cash 745,482
Total Cash Per Share 0.051
Total Debt 245,849
Total Revenue 4,707,877
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -3.15
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 0.97699
Two Hundred Day Average Change -0.70149
Two Hundred Day Average Change Percent -0.71801144
Type Disp Equity
Volume 206,323
Website https://www.ensysce.com
Zip 92,037