Annexon, Inc. (ANNX)Healthcare | Biotechnology | Brisbane, United States | NasdaqGS
4.97 USD
-0.28
(-5.333%) ⇩
(Aug. 28, 2026, 4 p.m.
EDT)
After hours: 5.01 +0.04 (0.805%) ⇧ (Aug. 28, 2026, 7:30 p.m. EDT) |
Hot Take ↕ | Aug. 22, 2026, 5:54 a.m. EDT
The investment case here is fundamentally broken. The company is hemorrhaging cash with negative free cash flow and operating cash flow, while returning negative returns on both assets and equity. The balance sheet shows significant debt relative to equity, and the stock has suffered a catastrophic 90% decline over the last five years. Although analysts project a massive upside based on potential trial success, the current reality is a deep value trap where the market has already priced in severe distress. The recent price action shows a slight bounce off lows, but the heavy options positioning suggests smart money is betting against further drops. Without a confirmed catalyst turning the corner on profitability, this remains a speculative gamble rather than an investment. |
| Model | MAE |
|---|---|
| MSTL ✓ | 0.061551 |
| AutoTheta | 0.062060 |
| AutoETS | 0.062176 |
| AutoARIMA | 0.062178 |
Forecast horizon: 45 days | Selected: MSTL
| Forecast Reliability | |
|---|---|
| Score | 40% |
| H-stat | 0.35 |
| Ljung-Box p | 0.000 |
| Jarque-Bera p | 0.926 |
| Excess Kurtosis | -0.06 |
| Attribute | Value |
|---|---|
| Sector | Healthcare |
| Debt to Equity Ratio | 13.249 |
| Market Cap | 942,208,256 |
| Forward P/E | -4.58 |
| Beta | 1.22 |
| Website | https://www.annexonbio.com |
As of Aug. 22, 2026, 5:54 a.m. EDT: Speculators are positioning aggressively for downside protection, evidenced by massive open interest in out-of-the-money puts (strikes $3.00 and $4.00) compared to calls. While there is some call volume at higher strikes ($7.00-$10.00), the overwhelming capital deployment is in put writing and buying, suggesting a consensus expectation of continued volatility and potential further declines rather than a breakout.
| Attribute | Value |
|---|---|
| 52 Week Change | 1.536232 |
| Address1 | 1,400 Sierra Point Parkway |
| Address2 | Building C Suite 200 |
| All Time High | 38.01 |
| All Time Low | 1.285 |
| Ask | 6.46 |
| Ask Size | 2 |
| Audit Risk | 7 |
| Average Analyst Rating | 1.6 - Buy |
| Average Daily Volume10 Day | 2,707,680 |
| Average Daily Volume3 Month | 3,618,343 |
| Average Volume | 3,618,343 |
| Average Volume10Days | 2,707,680 |
| Beta | 1.223 |
| Bid | 5.0 |
| Bid Size | 1 |
| Board Risk | 9 |
| Book Value | 1.066 |
| City | Brisbane |
| Compensation As Of Epoch Date | 1,767,139,200 |
| Compensation Risk | 8 |
| Country | United States |
| Crypto Tradeable | 0 |
| Currency | USD |
| Current Price | 4.97 |
| Current Ratio | 5.529 |
| Custom Price Alert Confidence | HIGH |
| Date Short Interest | 1,786,665,600 |
| Day High | 5.205 |
| Day Low | 4.95 |
| Debt To Equity | 13.249 |
| Display Name | Annexon |
| Earnings Timestamp | 1,786,537,800 |
| Earnings Timestamp End | 1,794,227,400 |
| Earnings Timestamp Start | 1,794,227,400 |
| Ebitda | -208,388,000 |
| Ebitda Margins | 0.0 |
| Enterprise To Ebitda | -3.89 |
| Enterprise Value | 810,698,432 |
| Eps Current Year | -1.05 |
| Eps Forward | -1.08499 |
| Eps Trailing Twelve Months | -1.07 |
| Esg Populated | 0 |
| Exchange | NMS |
| Exchange Data Delayed By | 0 |
| Exchange Timezone Name | America/New_York |
| Exchange Timezone Short Name | EDT |
| Fax | 650 636 9773 |
| Fifty Day Average | 5.4011 |
| Fifty Day Average Change | -0.43110037 |
| Fifty Day Average Change Percent | -0.07981714 |
| Fifty Two Week Change Percent | 153.6232 |
| Fifty Two Week High | 7.18 |
| Fifty Two Week High Change | -2.21 |
| Fifty Two Week High Change Percent | -0.30779946 |
| Fifty Two Week Low | 2.03 |
| Fifty Two Week Low Change | 2.9399998 |
| Fifty Two Week Low Change Percent | 1.4482758 |
| Fifty Two Week Range | 2.03 - 7.18 |
| Financial Currency | USD |
| First Trade Date Milliseconds | 1,595,597,400,000 |
| Float Shares | 163,794,476 |
| Forward Eps | -1.08499 |
| Forward P E | -4.580687 |
| Free Cashflow | -115,986,496 |
| Full Exchange Name | NasdaqGS |
| Full Time Employees | 92 |
| Fullday Change | -0.28 |
| Fullday Change Percent | -5.33334 |
| Fullday Price | 5.01 |
| Gmt Off Set Milliseconds | -14,400,000 |
| Governance Epoch Date | 1,785,542,400 |
| Gross Margins | 0.0 |
| Has Pre Post Market Data | 1 |
| Held Percent Insiders | 0.00424 |
| Held Percent Institutions | 1.02564 |
| Implied Shares Outstanding | 189,579,134 |
| Industry | Biotechnology |
| Industry Disp | Biotechnology |
| Industry Key | biotechnology |
| Is Earnings Date Estimate | 1 |
| Language | en-US |
| Last Fiscal Year End | 1,767,139,200 |
| Long Business Summary | Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. The company provides Tanruprubart, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington's disease; and in Phase 2a clinical trial for the treatment of amyotrophic lateral sclerosis. It is also developing ANX007, an antigen-binding fragment (Fab) that is in Phase 3 program for the treatment of patients with geographic atrophy; and ANX1502, a novel oral small molecule inhibitor, which is in Phase 1 clinical trials for autoimmune indications. In addition, it develops ANX009, a C1q-blocking Fab that is in Phase I clinical trial for treating patients with lupus nephritis. The company was incorporated in 2011 and is headquartered in Brisbane, California. |
| Long Name | Annexon, Inc. |
| Market | us_market |
| Market Cap | 942,208,256 |
| Market State | CLOSED |
| Max Age | 86,400 |
| Message Board Id | finmb_279883519 |
| Most Recent Quarter | 1,782,777,600 |
| Net Income To Common | -202,668,000 |
| Next Fiscal Year End | 1,798,675,200 |
| Non Diluted Market Cap | 995,290,453 |
| Number Of Analyst Opinions | 7 |
| Open | 5.18 |
| Operating Cashflow | -193,032,992 |
| Operating Margins | 0.0 |
| Overall Risk | 9 |
| Payout Ratio | 0.0 |
| Phone | 650 822 5500 |
| Post Market Change | 0.04000044 |
| Post Market Change Percent | 0.8048378 |
| Post Market Price | 5.01 |
| Post Market Time | 1,787,959,805 |
| Previous Close | 5.25 |
| Price Eps Current Year | -4.733333 |
| Price Hint | 4 |
| Price To Book | 4.6622887 |
| Profit Margins | 0.0 |
| Quick Ratio | 5.437 |
| Quote Source Name | Nasdaq Real Time Price |
| Quote Type | EQUITY |
| Recommendation Key | buy |
| Recommendation Mean | 1.6 |
| Region | US |
| Regular Market Change | -0.28 |
| Regular Market Change Percent | -5.33334 |
| Regular Market Day High | 5.205 |
| Regular Market Day Low | 4.95 |
| Regular Market Day Range | 4.95 - 5.205 |
| Regular Market Open | 5.18 |
| Regular Market Previous Close | 5.25 |
| Regular Market Price | 4.97 |
| Regular Market Time | 1,787,947,201 |
| Regular Market Volume | 1,617,732 |
| Return On Assets | -0.51542 |
| Return On Equity | -1.05261 |
| Sand P52 Week Change | 0.20504117 |
| Sector | Healthcare |
| Sector Disp | Healthcare |
| Sector Key | healthcare |
| Share Holder Rights Risk | 7 |
| Shares Outstanding | 189,579,134 |
| Shares Percent Shares Out | 0.1719 |
| Shares Short | 32,583,299 |
| Shares Short Previous Month Date | 1,784,073,600 |
| Shares Short Prior Month | 29,827,889 |
| Short Name | Annexon, Inc. |
| Short Percent Of Float | 0.18190001 |
| Short Ratio | 10.39 |
| Source Interval | 15 |
| State | CA |
| Symbol | ANNX |
| Target High Price | 27.0 |
| Target Low Price | 7.0 |
| Target Mean Price | 14.71429 |
| Target Median Price | 12.0 |
| Total Cash | 209,243,008 |
| Total Cash Per Share | 1.104 |
| Total Debt | 24,651,000 |
| Tradeable | 0 |
| Trailing Annual Dividend Rate | 0.0 |
| Trailing Annual Dividend Yield | 0.0 |
| Trailing Eps | -1.07 |
| Trailing Peg Ratio | None |
| Triggerable | 1 |
| Two Hundred Day Average | 5.3301 |
| Two Hundred Day Average Change | -0.36010027 |
| Two Hundred Day Average Change Percent | -0.06755976 |
| Type Disp | Equity |
| Volume | 1,617,732 |
| Website | https://www.annexonbio.com |
| Zip | 94,005 |