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Amylyx Pharmaceuticals, Inc. (AMLX)

Healthcare | Drug Manufacturers - Specialty & Generic | Cambridge, United States | NasdaqGS
34.74 USD -2.44 (-6.563%) ⇩ (Aug. 28, 2026, 4 p.m. EDT)
After hours: 34.85 +0.11 (0.317%) ⇧ (Aug. 28, 2026, 7:41 p.m. EDT)

Short-term:★★★★⯪Long-term:★★⯪☆☆Dividends:☆☆☆☆☆
Hot Take | Aug. 22, 2026, 4:15 a.m. EDT

The immediate narrative here is a classic 'dead cat bounce' turning into a speculative rally. After a catastrophic collapse from $93 in 2024 to roughly $2 in 2024, the stock staged a miraculous recovery to the high $30s in late August, erasing nearly all losses in a matter of weeks. This isn't driven by a turnaround in fundamentals—the company remains unprofitable with negative free cash flow and a negative forward P/E—so the move is purely speculative. However, the options market is screaming bullishness, with traders buying calls at strikes that would require a 30-50% gain from current levels, while almost no one is hedging with puts. This asymmetry suggests a high-risk, high-reward momentum play rather than a value investment. The statistical forecast model offers a weak lean upward, which aligns with the options flow but lacks the conviction to stand alone against the fundamental reality of the business. For investors, this is a binary bet on whether the Avexitide catalyst can drive a sustained re-rating, or if the recent surge was a final liquidation event. Given the lack of dividends and weak long-term earnings trajectory, this is strictly a short-to-intermediate term momentum trade, not a buy-and-hold opportunity.

Model Selection — Backtest MAE (log-scale, lower is better)
ModelMAE
AutoETS ✓0.160200
AutoARIMA0.160356
AutoTheta0.172159
MSTL0.207206

Forecast horizon: 45 days | Selected: AutoETS

Forecast Reliability
Score 20%
H-stat 149.17
Ljung-Box p 0.000
Jarque-Bera p 0.002
Excess Kurtosis 0.02
Attribute Value
Sector Healthcare
Debt to Equity Ratio 2.197
Market Cap 3,870,836,992
Forward P/E -30.09
Beta -0.21
Website https://amylyx.com

As of Aug. 22, 2026, 4:15 a.m. EDT: Speculators are aggressively positioning for a massive upside breakout, evidenced by heavy call volume at strikes significantly above the current price (e.g., $29, $35, $40) and a distinct lack of put writing beyond deep out-of-the-money levels. The implied volatility surface shows elevated premiums for near-term calls relative to the underlying's recent range, suggesting a 'long gamma' setup where traders expect a sharp move higher. Conversely, the put side is nearly dormant except for deep OTM hedges, indicating a consensus view that downside risk is limited or priced in via the recent crash.


Info Dump

Attribute Value
52 Week Change 2.725451
Address1 55 Cambridge Parkway
Address2 Suite 6W
All Time High 41.93
All Time Low 1.575
Ask 34.62
Ask Size 1
Audit Risk 6
Average Analyst Rating 1.2 - Strong Buy
Average Daily Volume10 Day 5,894,530
Average Daily Volume3 Month 2,436,477
Average Volume 2,460,874
Average Volume10Days 5,894,530
Beta -0.205
Bid 35.16
Bid Size 2
Board Risk 7
Book Value 2.148
City Cambridge
Compensation As Of Epoch Date 1,767,139,200
Compensation Risk 8
Country United States
Crypto Tradeable 0
Currency USD
Current Price 34.74
Current Ratio 12.12
Custom Price Alert Confidence HIGH
Date Short Interest 1,786,665,600
Day High 37.68
Day Low 34.475
Debt To Equity 2.197
Display Name Amylyx Pharmaceuticals
Earnings Call Timestamp End 1,786,017,600
Earnings Call Timestamp Start 1,786,017,600
Earnings Timestamp 1,786,019,400
Earnings Timestamp End 1,793,881,800
Earnings Timestamp Start 1,793,881,800
Ebitda -161,734,000
Ebitda Margins 0.0
Enterprise To Ebitda -24.096
Enterprise Value 3,897,203,968
Eps Current Year -1.49716
Eps Forward -1.15469
Eps Trailing Twelve Months -1.41
Esg Populated 0
Exchange NMS
Exchange Data Delayed By 0
Exchange Timezone Name America/New_York
Exchange Timezone Short Name EDT
Fifty Day Average 22.0896
Fifty Day Average Change 12.650402
Fifty Day Average Change Percent 0.5726859
Fifty Two Week Change Percent 296.37527
Fifty Two Week High 41.14
Fifty Two Week High Change -6.3999977
Fifty Two Week High Change Percent -0.1555663
Fifty Two Week Low 9.145
Fifty Two Week Low Change 25.595001
Fifty Two Week Low Change Percent 2.7987971
Fifty Two Week Range 9.145 - 41.14
Financial Currency USD
First Trade Date Milliseconds 1,641,565,800,000
Float Shares 97,214,381
Forward Eps -1.15469
Forward P E -30.085999
Free Cashflow -77,316,376
Full Exchange Name NasdaqGS
Full Time Employees 136
Fullday Change -2.44
Fullday Change Percent -6.56266
Fullday Price 34.85
Gmt Off Set Milliseconds -14,400,000
Governance Epoch Date 1,785,542,400
Gross Margins 0.0
Gross Profits -90,849,000
Has Pre Post Market Data 1
Held Percent Insiders 0.07141
Held Percent Institutions 0.93795997
Implied Shares Outstanding 111,423,048
Industry Drug Manufacturers - Specialty & Generic
Industry Disp Drug Manufacturers - Specialty & Generic
Industry Key drug-manufacturers-specialty-generic
Ipo Expected Date 2,022-01-07
Is Earnings Date Estimate 0
Language en-US
Last Fiscal Year End 1,767,139,200
Long Business Summary Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. The company also develops AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol which is phase 2 clinical trial for the treatment of wolfram syndrome, as well as in phase 2b/3 clinical trial to treat progressive supranuclear palsy; AMX0114, which is in phase 1 clinical trial for the treatment of amyotrophic lateral sclerosis; and long-acting GLP-1 receptor antagonist to treat post-bariatric hypoglycemia and other rare diseases. Further, it develops AMX0318, a GLP-1 receptor antagonist for the treatment of post-bariatric hypoglycemia and other rare diseaees. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.
Long Name Amylyx Pharmaceuticals, Inc.
Market us_market
Market Cap 3,870,836,992
Market State CLOSED
Max Age 86,400
Message Board Id finmb_317169670
Most Recent Quarter 1,782,777,600
Net Income To Common -152,092,000
Next Fiscal Year End 1,798,675,200
Non Diluted Market Cap 4,140,480,463
Number Of Analyst Opinions 11
Open 36.78
Operating Cashflow -126,577,000
Operating Margins 0.0
Overall Risk 8
Payout Ratio 0.0
Phone 617 682 0917
Post Market Change 0.109996796
Post Market Change Percent 0.31662863
Post Market Price 34.85
Post Market Time 1,787,960,494
Previous Close 37.18
Price Eps Current Year -23.203934
Price Hint 2
Price To Book 16.173185
Profit Margins 0.0
Quick Ratio 11.88
Quote Source Name Nasdaq Real Time Price
Quote Type EQUITY
Recommendation Key strong_buy
Recommendation Mean 1.16667
Region US
Regular Market Change -2.44
Regular Market Change Percent -6.56266
Regular Market Day High 37.68
Regular Market Day Low 34.475
Regular Market Day Range 34.475 - 37.68
Regular Market Open 36.78
Regular Market Previous Close 37.18
Regular Market Price 34.74
Regular Market Time 1,787,947,201
Regular Market Volume 1,361,345
Return On Assets -0.4413
Return On Equity -0.7473
Sand P52 Week Change 0.1966995
Sector Healthcare
Sector Disp Healthcare
Sector Key healthcare
Share Holder Rights Risk 8
Shares Outstanding 111,423,048
Shares Percent Shares Out 0.1205
Shares Short 13,425,106
Shares Short Previous Month Date 1,784,073,600
Shares Short Prior Month 12,265,993
Short Name Amylyx Pharmaceuticals, Inc.
Short Percent Of Float 0.1558
Short Ratio 7.01
Source Interval 15
State MA
Symbol AMLX
Target High Price 57.0
Target Low Price 20.0
Target Mean Price 42.36364
Target Median Price 42.0
Total Cash 250,760,000
Total Cash Per Share 2.251
Total Debt 5,255,000
Tradeable 0
Trailing Annual Dividend Rate 0.0
Trailing Annual Dividend Yield 0.0
Trailing Eps -1.41
Trailing Peg Ratio None
Triggerable 1
Two Hundred Day Average 16.22565
Two Hundred Day Average Change 18.51435
Two Hundred Day Average Change Percent 1.1410544
Type Disp Equity
Volume 1,361,345
Website https://amylyx.com
Zip 2,142